sentinel node biopsy


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

biopsy

 [bi´op-se]
removal and examination, usually microscopic, of tissue from the living body, often to determine whether a tumor is malignant or benign; biopsies are also done for diagnosis of disease processes such as infections.
Technique for endometrial biopsy. Longitudinal strips of the endometrium are sampled using an in-and-out and rotational motion. From Rakel, 2000.
aspiration biopsy one in which tissue is obtained by application of suction through a needle attached to a syringe.
brush biopsy one in which the sample is obtained by a brush with stiff bristles introduced through an endoscope, such as for a tissue sample from an inaccessible place such as the renal pelvis or bronchus.
chorionic villus biopsy chorionic villus sampling.
cone biopsy one in which an inverted cone of tissue is excised, as from the uterine cervix.
endoscopic biopsy removal of tissue by instruments inserted through an endoscope.
excisional biopsy removal of biopsy tissue by surgical cutting, such as a lumpectomy.
fine-needle aspiration biopsy aspiration biopsy using a fine needle. For superficial tissue such as the thyroid, breast, or prostate the needle is unguided, but for deep tissue it must be guided radiologically.
incisional biopsy biopsy of a selected portion of a lesion.
needle biopsy (percutaneous biopsy) one in which tissue is obtained by insertion through the skin of a special type of needle (see biopsy needle).
punch biopsy one in which tissue is obtained by a punch-type instrument.
sentinel node biopsy biopsy of a sentinel node (the first lymph node to receive lymphatic drainage from a malignant tumor). It is identified as follows: a dye and a radioactive substance are injected into the body, which causes certain nodes to “light up” like a sentinel, indicating that they are the most appropriate ones for examination. They are detected by both the light created by the dye and the radioactive substance that is monitored by a gamma camera. If the sentinel nodes do not contain malignant cells, this usually eliminates the need for removal of more distal nodes. Called also intraoperative lymphatic mapping.
shave biopsy biopsy of a skin lesion by excising it with a cut parallel to the surface of the surrounding skin.
stereotactic biopsy biopsy of the brain using a stereotactic technique to locate the biopsy site. This can be done as a minimally invasive surgery technique. The patient's head is held in a special rigid frame so that a probe can be directed into the brain through a small hole in the skull.
sternal biopsy biopsy of bone marrow of the sternum removed by puncture or trephining; see also sternal puncture.

sentinel node biopsy

biopsy preceded by injection of a dye or radioisotope adjacent to a tumor to identify for excision the primary nodes draining the area; used to determine the presence of lymph node metastasis without removing the entire lymph node basin.

sen·ti·nel node bi·op·sy

(sen'ti-nĕl nōd bī'op-sē)
Procedure preceded by injection of a dye or radioisotope proximal to a tumor to identify for excision the primary node draining the area; used to determine the extent of spread of a malignancy.

sentinel node biopsy

The identification and removal for examination of the SENTINEL NODE using a hand-held gamma-ray detector probe. It is claimed that examination of this single lymph node can accurately predict in 97.5 per cent of cases whether or not a breast cancer has spread to the lymph nodes. The false negative rate is 4.6 per cent. The method has also been used in the management of malignant melanoma. The sentinel node biopsy concept was originated by Professor Umberto Veronesi of the European Institute of Oncology, Milan, Italy.

Sentinel node biopsy

A newer procedure performed in order to determine whether breast cancer has spread to auxiliary (underarm) lymph nodes. A blue radioactive tracer and/or blue dye is injected into the area of the breast tumor. The lymphatic vessels carry the dye or radioactive material, to a "sentinel node". This sentinel node is thought to be the first lymph node receiving fluid from the tumor and the one most likely to contain cancer cells if the cancer has spread. Only if the sentinel node contains cancer cells are more lymph nodes removed.
Mentioned in: Lymphedema
References in periodicals archive ?
The study provides further weight to the argument in favour of sentinel node biopsy in patients with head and neck SCC, but it should be considered as an investigational tool pending validation by larger randomised clinical trials.
Hunerbein, "ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer," Breast Cancer Research and Treatment, vol.121, no.2, pp.373-378, 2010.
In a sentinel node biopsy, a surgeon injects a radioactive substance, a dye, or both near a tumor.
Under the new agreement, Cardiff will help establish a practical and standardised approach to sentinel node biopsy at Chongqing, which is the most advanced cancer hospital in Western China.
Randomized multkenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial.
"This technique of Sentinel Node Biopsy, combined with a brand new facility in the Northern Centre for Cancer Care means we can keep working to improve the levels of care we offer patients and using pioneering treatments."
In a sentinel node biopsy, a surgeon removes only one or a few of the sentinel nodes instead of the larger number of nodes typically removed for biopsy.
This new technique called sentinel node biopsy can reduce the arm swelling by 70% and reduce pain by 60% with no effect on survival rate.
(44) Thus, while sentinel node biopsy has demonstrated a role in staging, its use and the interpretation of results must be performed with these variables in mind.
The arrival of the gamma probe means that staff can now use it to carry out sentinel node biopsy.
But, says Rawlings, OThis can lead to complications like lymphedema, where women can lose some of the use of their arm.O Less risky is a new technique, called sentinel node biopsy. This involves removing the node the cancer is most likely to spread to first, enabling doctors to see the progress of the disease.
The cash raised will be spent on specialist equipment and training to carry out sentinel node biopsy work.