sentinel lymph node biopsy


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sentinel lymph node biopsy

dissection of the first lymph node in the chain of lymph nodes to catch metastatic tumor cells from a primary breast tumor or melanoma.

sentinel lymph node biopsy

A procedure, performed most often for breast cancer and less commonly for melanomas, in which a dye (Patent Blue V) and/or radioactive substance (99mTc-labelled colloid) is injected near a tumour; it flows into the sentinel lymph node (the first lymph node that cancer spreads to from a primary cancer). In the breast, 90% of the sentinel nodes are in the axilla, 10% in the internal mammary chain. The sentinel lymph is identified by a dye or a handheld gamma probe, removed and sent to pathology. If the sentinel node is negative for cancer (about 5% of cases are false negative), then it is likely that the tumour has not spread to the nodes and the considerable morbidity associated with removing the lymph nodes (e.g., marked lymphoedema with compromised quality of life, restricted shoulder movement, sensory loss, seroma formation, longer hospital stay and future risk of angiosarcoma) can be avoided.

Sentinel positivity
Macrometastasis: 50% risk of non-sentinel lymph node involvement.
Micrometastasis: Breast, 20% risk of non-sentinel lymph node involvement.

Micrometastasis
Melanoma
Predictors of poor prognosis
• Presence of infiltration of the sentinel node capsule;
• Tumour penetrative depth of > 2 mm;
• Largest tumour deposit of 30 cells.
Metastasis detected by immunocytochemistry, 9% risk of non-sentinel lymph node involvement.
References in periodicals archive ?
Meta-analysis of sentinel lymph node biopsy after preoperative chemotherapy in patients with breast cancer.
Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series.
The high axillary clearance rate in our patients is reflective of diagnostic concerns over concurrent invasive disease and the previously limited availability of sentinel lymph node biopsy facilities.
Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis.
Role for lymphatic mapping and sentinel lymph node biopsy in patients with thick (= 4 mm) primary melanoma.
With the validation of sentinel lymph node biopsy, the same staging information can be obtained with less morbidity and risk to the patient, and now that decisions regarding chemotherapy are often guided by molecular tumor profiling in an era of personalized medicine, there are other avenues to explore beyond aggressive surgeries.
Value of sentinel lymph node biopsy in breast ductal carcinoma in situ upstaged to invasive carcinoma," Breast Journal, vol.
SAN ANTONIO (IMNG)--Black women are significantly less likely to receive a sentinel lymph node biopsy than are white women - and significantly more likely to develop lymphedema, a large database study has determined.
The left mastectomy was a risk-reducing mastectomy with a sentinel lymph node biopsy.
The money will be spent improving the care of breast cancer patients and will be split between a sentinel lymph node biopsy probe and 'on the spot' assessment of lymph nodes, which in turn will help in avoiding second operations for the patients.
The guidelines also note that advanced imaging studies such as positron-emission tomography and computed tomography have lower sensitivity, compared with sentinel lymph node biopsy (SLNB).
Stage II B: The tumor is larger than 2 centimeters and less than 5 centimeters across and has spread to the lymph nodes under the arm and/or tiny amounts of cancer are found in internal mammary lymph nodes on sentinel lymph node biopsy.