sensitizing dose
sen·si·tiz·ing dose
in experimental anaphylaxis, the antigenic inoculum that renders an animal susceptible (sensitive) to anaphylactic shock following a subsequent inoculum (shocking dose) of the same antigen (anaphylactogen).
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It was anticipated that only the group of mice administered with 10 mg/kg showed a significant reduction in the mean values of skin thickness when compared with the mean values of other groups after applying a sensitizing dose of DNCB (Table III).
Among the factors that need to be considered are the age at which the sensitization dose(s) occurs, the time between sensitizing doses, and the route(s) of administration of the sensitizing dose.
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