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For the purpose of binary predictions, a composite reference was defined to classify a sensitizer as a compound that is categorized as having a human potency (HP) (Basketter et al.
The photoanode is normally comprised of Titanium Dioxide attached with sensitizer dye (Ruthenium N719) coated on a transparent conductive substrate.
The assay is based on the findings that skin sensitizers may act on the sensor protein Keap 1 and, via covalent bonding, modify its structure resulting in dissociation from the transcription factor Nrf2.
Researchers compared insulin sensitizers and insulin secretagogues in a study that included more than 25,000 patients with diabetes.
Along with lifestyle changes which include dietary and exercise regimen , insulin sensitizers are emerging as new and rational treatment modality.
All these factors are closely associated with the ground and excited electronic states of the dye sensitizer.
Considerations in relation to the therapeutic use of light activated killing of biofilms on host surfaces include: (1) direct toxicity of the sensitizer, (2) indirect toxicity of the sensitizer in terms of 'bystander' damage to adjacent host cells, (3) penetration into the biofilm, (4) light exposure time required to kill bacteria within in vivo biofilms, and (5) widespread relatively non-specific bacterial killing.
In this study, we investigated the photobleaching of pyropheophorbide methyl ester (PPME) and pyropheophorbide a (PPa) in a homogeneous solution of dimethylformamide (DMF) during PDT and estimated whether fluorescence photobleaching of the sensitizer or the formation of its photoproduct is appropriate for evaluating PDT dose.
Chain and leader of the research team that originally discovered rosiglitazone as a diabetes treatment commented: "If insulin sensitizer drugs such as Rosiglitazone proves affective in clinical trials those results will surely herald an important new therapeutic option to improve the quality of life for people all over the world who suffer from various dementias as well as normal age-related memory loss.
To conclude, Cisplatin appears to be better than Gemcitabine when used as a radio sensitizer for untreated locally advanced cervical cancer in terms of response and toxicity.
a biotechnology company focused on developing novel therapeutics for diabetes and related metabolic disorders, has begun a double-blind, placebo-controlled Phase 2a, proof-of-concept study for MBX-2044, an oral insulin sensitizer for the treatment of type 2 diabetes.
Metabolex is partnering with Ortho-McNeil, a Johnson & Johnson company, to develop and commercialize products for diabetes and metabolic disease, including Metabolex's lead drug candidate, metaglidasen, a second-generation insulin sensitizer now in a Phase 2/3 clinical trial.