senile plaque


Also found in: Dictionary, Thesaurus, Encyclopedia.

se·nile plaque

an obsolete term for neuritic plaque.
Farlex Partner Medical Dictionary © Farlex 2012

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

se·nile plaque

(sen'il plak)
A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Senile plaque

—Structures composed of parts of neurons surrounding brain proteins called beta-amyloid deposits found in the brains of people with AD.
Mentioned in: Alzheimer's Disease
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The sources of A[beta] accumulated in senile plaques are known to be multiple.
The senile plaques and neurofibrillary tangles are involved in damaging the neurons, but the exact mechanisms of their action are still largely unknown.
There has been some debate as to whether targeting Ap would be sufficient for an immunologically based therapy, because the role of senile plaques in the clinical picture appears to be just the tip of the iceberg.
This may be due to glucose dysregulation, accumulation of senile plaques, metabolic oxidation products associated with hyperglycemia, insufficient action or effect of insulin due to insufficient secretion, activity, or both, neuronal damage as a result of advanced glycosylated end-product production and oxidative stress, damage to vascular endothelium as a result of high osmotic stress induced by hyperglycemia which disrupts the blood-brain barrier causing local leakage of vascular substances and aggravates neuronal damage.
Hyman, "Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease," Neurology, vol.
DSCAM immunoreactivity has been found in the core of senile plaques and in surrounding synapses, suggesting some role for DSCAM in plaque formation (16).
It is well known that the different parts of the brain are not affected equally, at least according to the density and distribution of senile plaques and neurofibrillary tangles.
In particular, Zn, Cu, and Fe in senile plaques rims and cores have been found significantly elevated in AD [51].
AD is the most common senile dementia due to the formation of senile plaques and neurofibrillary tangles.
(1979) Dementia Parkinsonism syndrome with numerous Lewy bodies and senile plaques in cerebral cortex.
Grimm said studies have already shown that cholesterol promotes the formation of so-called senile plaques. These plaques, which are composed of proteins, particularly beta-amyloid proteins, deposit at nerve cells within the brain and are regarded as one of the main causes of Alzheimer's disease.
Unlike most mental disorders, neuropathological changes associated with AD represented by neurofibrillary tangles and senile plaques, were identified at the outset.