senile plaque

Also found in: Dictionary, Thesaurus, Encyclopedia.

se·nile plaque

Farlex Partner Medical Dictionary © Farlex 2012

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak)

A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Senile plaque

—Structures composed of parts of neurons surrounding brain proteins called beta-amyloid deposits found in the brains of people with AD.

Mentioned in: Alzheimer's Disease

Mentioned in ?

References in periodicals archive ?

The sources of A[beta] accumulated in senile plaques are known to be multiple.

The role of the blood-brain barrier in the pathogenesis of senile plaques in Alzheimer's disease

The senile plaques and neurofibrillary tangles are involved in damaging the neurons, but the exact mechanisms of their action are still largely unknown.

Alzheimer disease and other dementias

There has been some debate as to whether targeting Ap would be sufficient for an immunologically based therapy, because the role of senile plaques in the clinical picture appears to be just the tip of the iceberg.

Alzheimer's disease: is a vaccine possible?

This may be due to glucose dysregulation, accumulation of senile plaques, metabolic oxidation products associated with hyperglycemia, insufficient action or effect of insulin due to insufficient secretion, activity, or both, neuronal damage as a result of advanced glycosylated end-product production and oxidative stress, damage to vascular endothelium as a result of high osmotic stress induced by hyperglycemia which disrupts the blood-brain barrier causing local leakage of vascular substances and aggravates neuronal damage.

Effect of glycemic control on short-term memory in Type 2 diabetics

Hyman, "Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease," Neurology, vol.

Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease

DSCAM immunoreactivity has been found in the core of senile plaques and in surrounding synapses, suggesting some role for DSCAM in plaque formation (16).

Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice

It is well known that the different parts of the brain are not affected equally, at least according to the density and distribution of senile plaques and neurofibrillary tangles.

A[beta] Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development

In particular, Zn, Cu, and Fe in senile plaques rims and cores have been found significantly elevated in AD [51].

Redox Imbalance and Viral Infections in Neurodegenerative Diseases

AD is the most common senile dementia due to the formation of senile plaques and neurofibrillary tangles.

Beneficial neurological effects of Amyloban 3399: a product made from bioactive extracts of lion's mane (Hericium Erinaceum)

(1979) Dementia Parkinsonism syndrome with numerous Lewy bodies and senile plaques in cerebral cortex.

Lewy body disease and dementia with Lewy bodies

Grimm said studies have already shown that cholesterol promotes the formation of so-called senile plaques. These plaques, which are composed of proteins, particularly beta-amyloid proteins, deposit at nerve cells within the brain and are regarded as one of the main causes of Alzheimer's disease.

Plant sterols may prevent onset of Alzheimer's disease

Unlike most mental disorders, neuropathological changes associated with AD represented by neurofibrillary tangles and senile plaques, were identified at the outset.

Dementia--an 'old' disorder with new perspectives

Medical browser ?

Full browser ?

CITE

Site: Follow: Share:

Open / Close