senescent


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se·nes·cent

(sē-nes'ĕnt),
Growing old.

senescent

(sĭ-nĕs′ənt)
adj.
1. Growing old; aging.
2. No longer dividing. Used of a cell.

se·nes′cence n.

se·nes·cent

(sĕ-nes'ĕnt)
Growing old.

senescent

Ageing. The term ought not to imply physical or mental deterioration, but often does.
References in periodicals archive ?
Aminoethoxyvinylglycine, regardless of singleor multiple-dose application, and the harvesting date, maintains the quality of 'Baigent' apples stored under refrigeration for four months and seven days under room conditions, as it delays the ripening of fruits and reduces the farinaceous pulp and senescent degeneration incidence.
"But then on the other hand, we would like to find a way to remove senescent cells to promote healthy aging and better function," he said.
So far, studies conducted on mice have shown that by eliminating senescent cells, the mice becomes rejuvenated and can live a more functional life.
In the current study we aim to determine whether Filamin 3 (FLNB) and aminopeptidase N (CD13), two of the eleven proteins previously identified in the secretome of senescent BM- and A-MSCs, could be involved in the key functions of senescent cells.
** "Researchers have published findings from a safety and feasibility clinical trial on the removal of senescent cells from a small group of patients with pulmonary fibrosis.
Clearing away the backlog of senescent cells can help decrease inflammation throughout the body.
The other thing that has changed is that the field of senescence--and the recognition that senescent cells can be such drivers of aging--has finally gained acceptance.
"Preventing the build-up of senescent glia can block the cognitive decline and neuro-degeneration normally experienced by these mice," Jay Penney and Li-Huei Tsai, both from MIT, wrote in a comment, also in Nature.
Based in the Netherlands, Cleara has partnered with Dr Peter de Keizer from the University Medical Center in Utrecht, Dr Marco Demaria from the University Medical Center in Groningen and Dr Tobias Madl from the Medical University of Graz to engage in senescent cells discovery operations.
As expected, the p21 protein was highly expressed in H[sub]2O[sub]2-induced prematurely senescent RPE cells compared to the control group ( P < 0.001).
In 2014, Demaria et al.'s group [8] showed that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA).
Importantly, the role of senescent stromal cells in the tumor microenvironment is coming into light due to their ability to drive the unrestrained growth of tumors, which cause a differential response of cancer cells to anticancer drugs [11, 12].