Semustine | definition of semustine by Medical dictionary
the methyl analog of lomustine
, a cytotoxic alkylating agent
used as an antineoplastic agent
, primarily for treatment of brain tumors, colorectal carcinoma, gastric carcinoma, Hodgkin's disease, and malignant melanoma.
A nitrosourea antineoplastic agent resembling carmustine (BCNU) and lomustine (CCNU).
References in periodicals archive
Thus, chemo- and radiotherapy (or other means) are the preferred approach for treating advanced GC; common drugs include oxaliplatin, 5FU, and semustine
One arm received adjuvant chemotherapy with 5-FU plus semustine plus vincristine and the other arm received adjuvant radiotherapy.
1988  2002  1998  Study design Multicentre Multicentre Multicentre RCT RCT RCT Number of 555 289 834 patients Stage of II and III II and III II and III rectal cancer Intervention Arm I: Surgery Surgery arm(s) surgery adjuvant CT adjuvant CT adjuvant CT arm 2: surgery adjuvant RD Control arm Surgery Surgery Surgery Chemotherapy 5-FU + UFT MMC + regimen semustine + UFT vincristine Intention to Not Not Not treat analysis reported reported reported Outcomes DSF and OS DSF and OS DSF and OS Risk of bias Low Low Low Methodological High High High quality * Hamaguchi et al.