Caneguim B, Cerri P, Spolidorio L, Miraglia S, Sasso-Cerri E (2009) Structural alterations in the seminiferous tubules
of rats treated with immunosuppressor tacrolimus.
The primary type A diploid spermatogonia lie at the base of the seminiferous tubules
, where they can either renew themselves and/or differentiate into type B spermatogonia (Phillips et al.
Although the testes of mammals present standard structure for several species, there is great variation in relation to volumetric proportion of its various components, especially in relation to the seminiferous tubules
, Leydig cells and proportion and disposition of vessels and lymphatics spaces (RUSSELL et al.
The first phase is during the first week, where the transplanted cells have a random distribution through the seminiferous tubules
and a few of them colonize the basal membrane.
The 2TD were presented with the tubules lost, the basement membrane and some seminiferous tubules
with thickened basement membrane had less number of epithelial cells in fact much of the epithelium lining tubules are vacuolated.
Non-parametric univariate analyses Kruskal-Wallis ANOVA (Sokal and Rohlf, 1981) were used to test for statistically significant differences between testicular volume, body length and the diameter of the seminiferous tubules
mechanical support to the seminiferous tubules
and blood vessels, production of testosterone by interstitial cells (Leydig cells), participation in the sustentacular cell barrier and regulation of the sustentacular cell (Sertoli cell) functions.
In another study,6 dexamethasone-induced spermatogenesis defects including epithelial vacuolisation, sloughing of germ cells, reduction of seminiferous tubule
diameter, reduction in the number of sperm heads and significant maturation arrest were in agreement with the present study.
Previous studies compared the testis weight, seminiferous tubule
length, germ cell development and numbers of Sertoli and Leydig cells and seminiferous epithelium cycle length in mules and donkeys (Neves et al.
The findings of the current research suggested that morphine could cause harmful effects on the testis weight, sperm parameters and seminiferous tubule
architecture in the male mice, while resveratrol tended to reclaim them.
The clusters of Leydig cells are found to be located in the angular spaces among the seminiferous tubules
and are frequently associated with blood vessels.
Histopathologically, the microscopic observations of the testis in the control group showed normal appearance of seminiferous tubules
(STs), spermatogenic cells and interstitial cells (Figure 1a).