semiconservative replication

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sem·i·con·ser·va·tive rep·li·ca·tion

replication in which a double-stranded DNA (dsDNA) produces two daughter dsDNAs, each of which contains one of the original chains and one newly synthesized strand.

semiconservative replication

(sĕm′ē-kən-sûr′və-tĭv, sĕm′ī-)
The normal process of DNA synthesis, in which the two original strands of the molecule separate, and each strand acts as a template for the synthesis of a new, complementary strand. Each new DNA molecule consists of one old strand and one new strand.


1. a turning back of a part so as to form a duplication.
2. repetition of an experiment to ensure accuracy.
3. the process of duplicating or reproducing, as replication of an exact copy of a polynucleotide strand of DNA or RNA. See also deoxyribonucleic acid.

replication bubble
seen in electron micrographs of DNA in replicating eukaryotic cells, suggesting bidirectional growth.
conservative replication
an invalid hypothetical model for DNA replication in which both strands of the double helix remain together after replication. DNA replicationoccurs via semiconservative mechanisn in which one parental and one nascent strand are produced.
dispersive replication
in DNA replication, a hypothetical model in which nucleotides of the parental DNA strand would be randomly scattered along the strands of the newly synthesized DNA, as compared with semiconservative and conservative DNA replication.
replication fork
a 'y' shaped structure in replicating DNA, the arms of which are the newly synthesized DNA molecules composed of one parental and one nascent strand and the stem of which is the parental DNA that is progressively unwinding as it is copied.
semiconservative replication
a reference to the preservation of one of the original parental DNA strands in each of the two nascent DNA molecules produced following DNA replication.