semaphorin


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semaphorin

(sem-a-fōr'in),
A family of membrane proteins including S-I, S-II, S-III, S-III/D and collapsing 1 that guide growth cones of axons by selective repulsion.
References in periodicals archive ?
Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.
Although Goodman found his first semaphorin in insects, other chemical signposts in the semaphorin family now include collapsin, which Raper found first in chicks, and semaphorin III, which exists in humans.
When prostate cancer cells overproduce semaphorin 4F, new nerves result.
Cellular Mechanisms of Semaphorin 3E-Plexin-D1 Signaling in Basal Ganglia Circuitry Formation and Neurodegenerative Diseases* Chenghua Gu, D.
VX15/2503 is a novel humanized monoclonal antibody targeting the multi-functional protein semaphorin 4D (SEMA4D), and represents the second clinical trial for this investigational drug.
D, of Yale University's Division of Pulmonary and Critical Care Medicine: His study is Semaphorin 7a and Alternative Macrophage Activation in Idiopathic Pulmonary Fibrosis.
Third, two classes of molecular inhibitors to growth are present in the lesioned CNS to actively block axonal growth: inhibitory extracellular matrix proteins, including chondroitin sulfate proteoglycans, and inhibitory proteins present on adult myelin, including Nogo, myelin-associated glycoprotein, oligodendrocyte-myelin glycoprotein, netrin, semaphorins, Wnt proteins, and others [64-66].
Axons--the long extensions formed by growing brain cells--display neuropilin-1, which reacts to proteins called semaphorins or collapsins, which serve as axonal stop signs.