semaphorin


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semaphorin

(sem-a-fōr'in),
A family of membrane proteins including S-I, S-II, S-III, S-III/D and collapsing 1 that guide growth cones of axons by selective repulsion.
References in periodicals archive ?
Semaphorin signaling appears to shape the physical architecture of the brain and influence circuitry governing body weight.
Signaling by semaphorin receptors: cell guidance and beyond.
Tanaka, "Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration," The American Journal of Pathology, vol.
Moreover, besides its role as receptor for class 3 semaphorins, NRP1 is also considered a coreceptor for some growth factors, such as VEGF or PDGF.
Currently, a number of evidences indicated that neural guidance cues and their binding sites, such as ephrin, Netrin, and semaphorins, function as angiogenic regulators.
Goodman, "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules," Cell, vol.
Tessier-Lavigne," Neuropilin is a receptor for the axonal chemorepellent Semaphorin III," Cell, vol.
Hoyland, "Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc," Arthritis Research & Therapy, vol.
Besides VEGF, TAMs release a panel of proangiogenic factors which include TNF-[alpha], basic fibroblast growth factor (bFGF), CXCL8/IL-8, thymidine phosphorylase (TP), adrenomedullin (ADM), and semaphorin 4D (Sema4D) [88-91] (Figure 2).
(2000) Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.
SEMA3A encodes for semaphorin 3A, a protein that interacts with neuropilins.