self-tolerance


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self-tolerance

 [self-tol´er-ans]
immunological tolerance to self-antigens.

hor·ror au·to·tox·'i·cus

a term introduced by Ehrlich, meaning that immunity is directed against foreign materials but not against the constituents of one's own body; exceptions to this concept are the autoallergic reactions and diseases.
Synonym(s): self-tolerance
[L., dread of self-poisoning]

self-tolerance

(sĕlf′tŏl′ər-əns)
n.
Tolerance by the body's immune system to its own cells and tissues.

self-tolerance

immunological tolerance to the body's own ANTIGENS (self antigens), achieved by preventing the production of functional B-CELLS and T-CELLS reactive to such antigens. Thus the body is not able to direct an IMMUNE RESPONSE against self antigens. Breakdown of this mechanism leads to AUTOIMMUNITY and production of autoantibodies against self antigens.
References in periodicals archive ?
Role in T-cell development and central T-cell self-tolerance. Ann N Y Acad Sci 2000;917:710-23.
Its low level of expression on both T and B regulatory cells in autoimmune diseases, such as SLE and RA, contributes to the failure of self-tolerance in these diseases.
Mice transgenic for the Ig H chain 3H9 and its variants established by Weigert and colleagues are useful in analyzing the self-tolerance of B cells producing anti-nuclear autoantibodies, because these Ig H chains generate anti-nuclear antibodies by associating with various Ig L chains.
Based on this theory, immunological self-tolerance is caused by the deletion of self-reactive clones, whereas autoimmunity arises by the emergence of self-reactive clones [4].
Breakdown of self-tolerance and the pathogenesis of autoimmunity.
"Essentially we've shown there's a big hole in self-tolerance when it comes to cross-reactive autoantibodies that can attack organ-specific targets," Associate Prof Brink said in a statement.
Thus, the investigators hypothesized, "if you are deficient in vitamin D, it may lead to a break of self-tolerance and the development of autoimmunity," Dr.
Severe thrombocytopenia often develops in dogs as an autoimmune process, in which the immune system loses self-tolerance and destroys platelets as if they were foreign invaders.
There is accumulating evidence that naturally arising CD4+CD25+regulatory T (Treg) cells play a crucial role in the maintenance of immunologic self-tolerance and negative control of immune responses [8].