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immunological tolerance to self-antigens.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
a term introduced by Ehrlich, meaning that immunity is directed against foreign materials but not against the constituents of one's own body; exceptions to this concept are the autoallergic reactions and diseases.
[L., dread of self-poisoning]
Farlex Partner Medical Dictionary © Farlex 2012
Tolerance by the body's immune system to its own cells and tissues.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
self-toleranceimmunological tolerance to the body's own ANTIGENS (self antigens), achieved by preventing the production of functional B-CELLS and T-CELLS reactive to such antigens. Thus the body is not able to direct an IMMUNE RESPONSE against self antigens. Breakdown of this mechanism leads to AUTOIMMUNITY and production of autoantibodies against self antigens.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005