Role in T-cell development and central T-cell self-tolerance
. Ann N Y Acad Sci 2000;917:710-23.
Its low level of expression on both T and B regulatory cells in autoimmune diseases, such as SLE and RA, contributes to the failure of self-tolerance
in these diseases.
Mice transgenic for the Ig H chain 3H9 and its variants established by Weigert and colleagues are useful in analyzing the self-tolerance
of B cells producing anti-nuclear autoantibodies, because these Ig H chains generate anti-nuclear antibodies by associating with various Ig L chains.
Based on this theory, immunological self-tolerance
is caused by the deletion of self-reactive clones, whereas autoimmunity arises by the emergence of self-reactive clones .
Breakdown of self-tolerance
and the pathogenesis of autoimmunity.
Regulatory T Cells: Minireview Key Controllers of Immunologic Self-Tolerance
. Cell 2000; 101:455-458.
"Essentially we've shown there's a big hole in self-tolerance
when it comes to cross-reactive autoantibodies that can attack organ-specific targets," Associate Prof Brink said in a statement.
Thus, the investigators hypothesized, "if you are deficient in vitamin D, it may lead to a break of self-tolerance
and the development of autoimmunity," Dr.
T-cells are designed with an in-built safety mechanism, called self-tolerance
, which normally stops them from accidentally reacting with healthy tissues.
Severe thrombocytopenia often develops in dogs as an autoimmune process, in which the immune system loses self-tolerance
and destroys platelets as if they were foreign invaders.
There is accumulating evidence that naturally arising CD4+CD25+regulatory T (Treg) cells play a crucial role in the maintenance of immunologic self-tolerance
and negative control of immune responses .