self-tolerance

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self-tolerance

[self-tol´er-ans]

immunological tolerance to self-antigens.

hor·ror au·to·tox·'i·cus

a term introduced by Ehrlich, meaning that immunity is directed against foreign materials but not against the constituents of one's own body; exceptions to this concept are the autoallergic reactions and diseases.

Synonym(s): self-tolerance

[L., dread of self-poisoning]

Farlex Partner Medical Dictionary © Farlex 2012

self-tolerance

(sĕlf′tŏl′ər-əns)

Tolerance by the body's immune system to its own cells and tissues.

self-tolerance

immunological tolerance to the body's own ANTIGENS (self antigens), achieved by preventing the production of functional B-CELLS and T-CELLS reactive to such antigens. Thus the body is not able to direct an IMMUNE RESPONSE against self antigens. Breakdown of this mechanism leads to AUTOIMMUNITY and production of autoantibodies against self antigens.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive ?

Role in T-cell development and central T-cell self-tolerance. Ann N Y Acad Sci 2000;917:710-23.

Immune Tolerance Therapy: A New Method for Treatment of Traumatic Brain Injury

Its low level of expression on both T and B regulatory cells in autoimmune diseases, such as SLE and RA, contributes to the failure of self-tolerance in these diseases.

Semaphorin3A: A potential therapeutic tool in immune-mediated diseases

Mice transgenic for the Ig H chain 3H9 and its variants established by Weigert and colleagues are useful in analyzing the self-tolerance of B cells producing anti-nuclear autoantibodies, because these Ig H chains generate anti-nuclear antibodies by associating with various Ig L chains.

Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen

Based on this theory, immunological self-tolerance is caused by the deletion of self-reactive clones, whereas autoimmunity arises by the emergence of self-reactive clones [4].

The Histone Modification Code in the Pathogenesis of Autoimmune Diseases

Breakdown of self-tolerance and the pathogenesis of autoimmunity.

IMMUNOMODULATORY ACTIVITY OF FLURBIPROFEN IN MICE

Regulatory T Cells: Minireview Key Controllers of Immunologic Self-Tolerance. Cell 2000; 101:455-458.

Genetic susceptibility to multiple sclerosis: the role of [FOXP.sub.3] gene polymorphism/Multipl skleroza genetik yatkinlik: [FOXP.sub.3] gen polimorfizminin rolu

"Essentially we've shown there's a big hole in self-tolerance when it comes to cross-reactive autoantibodies that can attack organ-specific targets," Associate Prof Brink said in a statement.

How infection triggers autoimmune disease

Thus, the investigators hypothesized, "if you are deficient in vitamin D, it may lead to a break of self-tolerance and the development of autoimmunity," Dr.

Low Vit D may trigger inflammatory arthritis

T-cells are designed with an in-built safety mechanism, called self-tolerance, which normally stops them from accidentally reacting with healthy tissues.

Discovery leads the way to understanding the defensive role of T-cells; Health Wales is highlighting the work of Welsh Crucible researchers - the cream of Welsh research talent. Dr David Cole explains his research and why T-cells could hold the key to curing cancer

Severe thrombocytopenia often develops in dogs as an autoimmune process, in which the immune system loses self-tolerance and destroys platelets as if they were foreign invaders.

Canine blood disorders: veterinarians recommend annual exams that include a blood count and chemistry profile. Here's why

There is accumulating evidence that naturally arising CD4+CD25+regulatory T (Treg) cells play a crucial role in the maintenance of immunologic self-tolerance and negative control of immune responses [8].