Like
selegiline, it has effects on dopamine levels.
Neuroprotective Effect of Ceftriaxone and
Selegiline on Scopolamine Induced Cognitive Impairment in Mice.
* The MAO-B inhibitors
selegiline and rasagiline may also be considered for initial therapy but are more commonly used as adjunct therapy.
In each study, the randomized patient population was divided into 3 subgroups based on the use of concomitant medications at study entry: a dopaminergic agonist group, a MAO-B inhibitor group (rasagiline and
selegiline), and an amantadine group.
(a)
Selegiline (0.038 [micro]M); (b) 4a (0.42 [micro]M); (c) 4b (0.36 [micro]M); (d) 4c (0.69 [micro]M).
Levodopa, dopamine agonists (apomorphine, bromocriptine, cabergoline), monoamine oxidase B inhibitors (
selegiline, amantadine), anticholinergics (biperiden, bornaprine), peripheral dopamine blockers (domperidone) and catecholamine methyltransferase inhibitors are used in the medical treatment of the disease to maintain the balance between the cholinergic and dopaminergic activity (5).
Standards of moclobemide and
selegiline are used as positive controls for MAO-A and MAO-B inhibition, respectively.
Recently, our research group has demonstrated the prospective of drug loaded nanospheres embedded films in enhancing the bioavailability of
selegiline when delivered through buccal route (9).
But then they jump to suggestions that have not yet been proven, including supplementation with "huge doses of vitamin D" and melatonin, plus metformin (a diabetes drug) and
selegiline (a drug used to treat early Parkinson's and depression).
Legal medication that could result in drug-driving charge | |Amphetamines (eg Dexamphetamine or
Selegiline) | Clonazepam | | |Diazepam | | Flunitrazepam | | Lorazepam | | | Morphine or opiate and opioidbased drugs (eg codeine, tramadol or fentanyl) | |Oxazepam | | Temazepam
Considering that this patient mainly suffered from the extrapyramidal symptom, she was prescribed levodopa 450 mg/d and
selegiline 10 mg/d.
Dopaminergic medications, such as
selegiline or pramipexole, are used for early-stage Parkinsons disease (PD), and also to slow the progression of symptoms in dementia.
