selegiline


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selegiline

 [sĕ-lej´ĭ-lēn]
an agent used in treatment of parkinsonism; used as the hydrochloride salt in conjunction with levodopa and carbidopa.

selegiline

/se·le·gil·ine/ (sĕ-lej´ĭ-lēn) an antiparkinsonian agent used as the hydrochloride salt in conjunction with levodopa and carbidopa.

selegiline

(sə-lĕj′ə-lēn′)
n.
A selective monoamine oxidase inhibitor, C13H17N, used transdermally as an antidepressant and in its hydrochloride form in conjunction with levodopa and carbidopa to treat patients with Parkinson's disease.

deprenyl

Alternative pharmacology
A prescription drug used to treat Parkinson’s disease, which has acquired currency among some practitioners of alternative medicine as an anti-ageing substance; deprenyl acts on the substantia nigra., a region of the brain that is believed to age more rapidly than others, by blocking the degradation of dopaminergic neurotransmitters.

selegiline

l-Deprenyl Neuropharmacology A selective monoamine oxidase type B inhibitor which, with l-dopa, may be useful for early symptomatic treatment of parkinsonism

selegiline

A selective MONOAMINE OXIDASE INHIBITOR drug used in the treatment of PARKINSONISM. Selegiline is thought to retard the breakdown of DOPAMINE. Brand names are Eldepryl and Vivapril.

selegiline (seˑ·l·gi·lēnˈ),

n an MAO-B inhibitor used to treat Parkinson's disease. It also acts as an antioxidant and an immunostimulant, protects nerve tissue from degeneration, and has positive effects on cognition. Also called
deprenyl or
l-deprenyl.
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5 to 5 5 to 60 to 90 8 AM and hours mg 10 mg mg 12 pm Modafinil <24 100 to 200 200 to 400 mg Single hours mg 300 early mg morning dose Transdermal Weeks 6mg/d 6 to 12 mg/d Daily selegiline 12 mg/d Source: Reference 32
Assessing and treating depression in palliative care patients: antidepressants, psychotherapy can improve dying patients' quality of life
5 mg/day orally disintegrating selegiline, and 6 patients were taking 1.
Selegiline reduces some adverse events in Parkinson's
Selegiline taken in the orally disintegrating form significantly decreased the amount of levodopa nonresponse time, compared with placebo in two phase III, randomized, double-blind trials, reported Dr.
Selegiline serves as effective adjunct for PD symptoms
Bodkin, who has been involved in studying the transdermal preparation of selegiline for more than a decade.
Emsam, Eraxis
Table 1 Recommended dosages of monoamine oxidase inhibitors Medication Starting dosages Usual therapeutic_dosage Selegiline transdermal 10 mg twice a day 30 to 60 mg/d Tranykyprornine 15 mg twice a day 45 to 90mg/d Isocarboxazid 6 mg patch/d 6 to 12 mg patch/d Pheneizine 10 mg, 2 or 3 30 to 60 mg/d times a day Source: Adapted from reference 8
Forgotten treatment for depression: increased knowledge of MAOIs has made these agents worthy of reconsideration
The oral formulation of selegiline that is marketed as Eldepryl for Parkinson's disease is an effective antidepressant only at doses that are too high to disregard dietary restrictions, Dr.
Emsam
Transdermal selegiline may make it possible to achieve the antidepressant efficacy of a monoamine oxidase inhibitor without the dietary restrictions and acute hypertensive risks that have been largely responsible for the fall from favor of this drug class, Dr.
Rx delivery systems in pipeline for depression, ED
Five patients were on carbidopa/levodopa, two on dextroamphetamine (for fatigue), three on selegiline, one on amantadine and three were taking a diuretic.
Pramipexole and weight monitoring
The study, "A Controlled Trial of Selegiline, Alpha-Tocopherol or Both as Treatment for Alzheimer's Disease," shows that just two years of vitamin E supplementation was 25% more effective than the prescription drug selegiline.
Researchers make case for vitamins
19) Transdermal selegiline is contraindicated with tramadol.
Epileptic and depressed
Regarding the future, selegiline (Emsam), corticotrophin-releasing hormone antagonists, citicoline, clozapine (Clozaril), risperidone (Risperdal), and lofexidine (Britlofex) are among the agents currently being studied with NIDA funding.
Buspirone, fluoxetine may counter cannabis use

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