selective progesterone receptor modulator

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selective progesterone receptor modulator



A class of medications that attach to cellular binding sites for the hormone progesterone, and either stimulate those sites, block them, or both block and stimulate them. They have a variety of uses in obstetrics and gynecology. Antagonist (blocking) agents like mifepristone can induce abortion. Agonist (receptor-stimulating) drugs may be used to treat uterine fibroids.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata.
Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy.
Dolmans, "With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice?" Fertility and Sterility, vol.
Fauser, "Selective progesterone receptor modulators in reproductive medicine: Pharmacology, clinical efficacy and safety," Fertility and Sterility, vol.
A selective progesterone receptor modulator (SPRM), asoprisnil is thought to work by inhibiting blood flow at the endometrial level, thus significantly reducing bleeding associated with leiomyomas.
Esmya, like other selective progesterone receptor modulators, works by blocking the progesterone receptors that are located within the uterus and throughout the human body.
The company said FIBRISTAL belongs to a class of medications called selective progesterone receptor modulators (SPRMs).
Future therapies include selective progesterone receptor modulators such as asoprisnil, which induce amenorrhea without side effects of hypoestrogenism and control uterine prostaglandins.

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