selective estrogen receptor modulator


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Related to selective estrogen receptor modulator: tamoxifen

modulator

 [mod´u-la″ter]
a specific inductor or agent that brings out characteristics peculiar to a definite region.
selective estrogen receptor modulator (SERM) an agent that activates some estrogen receptors but not others, thereby having estrogenlike effects on target tissues (such as bone) without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator (SERM),

pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

selective estrogen receptor modulator

n.
Abbr. SERM Any of a group of nonsteroidal drugs, such as raloxifene and tamoxifen, that bind to estrogen receptors and act in some cases as estrogen agonists and in others as estrogen antagonists.

selective estrogen receptor modulator (SERM)

an agent that activates some estrogen receptors but not others, thereby having estrogen-like effects on target tissues without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator

Designer estrogen, SERM Therapeutics A drug–eg, idoxifene, raloxifene–Evista®, which, like estrogen, prevents bone loss and ↓ cholesterol but, unlike estrogen, does not stimulate the endometrium and breast and thus does not ↑ risk of breast and endometrial CA. See Estrogen receptor, Raloxifene.

se·lec·tive es·tro·gen re·cep·tor mod·u·la·tor

(SERM) (sĕ-lek'tiv es'trŏ-jen rĕ-sep'tŏr mod'yū-lā'tŏr)
Pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

Selective estrogen receptor modulator

A hormonal preparation that offers the beneficial effects of hormone replacement therapy without the increased risk of breast and uterine cancer associated with HRT.
Mentioned in: Osteoporosis
References in periodicals archive ?
Selective estrogen receptor modulators and postmenopausal women's health.
But interest in the drug, which is a benzothiophene-derivative selective estrogen receptor modulator, was revived after reports that longterm tamoxifen use was associated with endometrial cancer.
If highly sensitive estradiol tests were to become widely available in clinical practice, physicians might be able to use them in patients to help decide whether the best approach to preventing osteoporosis while minimizing treatment-related risk is exogenous estrogen, a bisphosphonate, or a selective estrogen receptor modulator.
The drug of choice for prevention of breast cancer recurrence, tamoxifen is a selective estrogen receptor modulator [SERM] that has been linked to an increased incidence of endometrial cancer in postmenopausal women.
In the Phase III clinical trial, treatment with toremifene 80 mg, a selective estrogen receptor modulator, resulted in increased bone mineral density compared to placebo in men with prostate cancer on ADT and, most importantly, toremifene 80 mg treatment significantly reduced the risk of fracture.
April: Wyeth received approval from the European Commission (EC) for CONBRIZA[TM] (bazedoxifene), a selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in post-menopausal women at increased risk of fracture.
Toremifene 80 mg is an oral selective estrogen receptor modulator which GTx seeks to market for the prevention of bone fractures in men with prostate cancer on androgen deprivation therapy (ADT).
Nasdaq: GTXI) announced today that the United States Food and Drug Administration has accepted for filing and review the New Drug Application (NDA) for toremifene 80 mg, an oral selective estrogen receptor modulator, which GTx seeks to market for the prevention of bone fractures in men with prostate cancer on androgen deprivation therapy (ADT).
Lasofoxifene is a selective estrogen receptor modulator, or SERM, in the same chemical class as raloxifene.
SERCAs have a unique biological and activity profile compared to Selective Estrogen Receptor Modulators (SERMs) and Selective Estrogen Receptor Degraders (SERDs).
Tamoxifen belongs to selective estrogen receptor modulators (SERMs) class of drugs, which is having both estrogenic and anti-estrogenic effects.

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