selective estrogen receptor modulator


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Related to selective estrogen receptor modulator: tamoxifen

modulator

 [mod´u-la″ter]
a specific inductor or agent that brings out characteristics peculiar to a definite region.
selective estrogen receptor modulator (SERM) an agent that activates some estrogen receptors but not others, thereby having estrogenlike effects on target tissues (such as bone) without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator (SERM),

pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

selective estrogen receptor modulator

n.
Abbr. SERM Any of a group of nonsteroidal drugs, such as raloxifene and tamoxifen, that bind to estrogen receptors and act in some cases as estrogen agonists and in others as estrogen antagonists.

selective estrogen receptor modulator

Designer estrogen, SERM Therapeutics A drug–eg, idoxifene, raloxifene–Evista®, which, like estrogen, prevents bone loss and ↓ cholesterol but, unlike estrogen, does not stimulate the endometrium and breast and thus does not ↑ risk of breast and endometrial CA. See Estrogen receptor, Raloxifene.

se·lec·tive es·tro·gen re·cep·tor mod·u·la·tor

(SERM) (sĕ-lek'tiv es'trŏ-jen rĕ-sep'tŏr mod'yū-lā'tŏr)
Pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

Selective estrogen receptor modulator

A hormonal preparation that offers the beneficial effects of hormone replacement therapy without the increased risk of breast and uterine cancer associated with HRT.
Mentioned in: Osteoporosis
References in periodicals archive ?
Selective estrogen receptor modulators for prevention and treatment of osteoporosis, http://www.uptodate.com/ contents/selective-estrogen-receptor-modulators-for -prevention-and-treatment-of-osteoporosis.
Garcia-Segura, "Selective estrogen receptor modulators as brain therapeutic agents," Journal of Molecular Endocrinology, vol.
Lam et al., "Cardioprotective effects of long-term treatment with raloxifene, a selective estrogen receptor modulator, on myocardial ischemia/ reperfusion injury in ovariectomized rats," Menopause, vol.
Other scientists are less willing to give ER-beta a role in the actions of designer estrogens, which are also called selective estrogen receptor modulators, or SERMS.
Tamoxifen and selective estrogen receptor modulators cause certain "anti-estrogen" type effects.
Nawaz et al., "A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats," Journal of Bone and Mineral Research, vol.
2011), with much less effect on uterine weight than 17[beta]-estradiol ([E.sub.2]), highlighting its potential utility as a selective estrogen receptor modulator that might have fewer side effects than [E.sub.2] itself.
Two selective estrogen receptor modulator (SERM) drugs--tamoxifen and raloxifene (Evista)--are approved for breast cancer prevention, but they are little used for that purpose.
Its drug candidate, Menerba (formerly MF-101), represents a class of receptor sub-type selective estrogen receptor modulator (SERM), for the treatment of vasomotor symptoms of menopause, or hot flashes.
Soybeans contain a compound daidzein that certain bacteria living within the digestive tract of some individuals can metabolize, or convert, into Natural S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman], a compound thought to act as a selective estrogen receptor modulator (SERM).
The Oncologic Drugs Advisory Committee recommended approval of raloxifene, a selective estrogen receptor modulator. Raloxifene was originally approved by the FDA in 1997 to prevent and treat osteoporosis in postmenopausal women.
Tokyo, Japan, June 30, 2006 - (JCN) - Eisai announced June 29 that it signed a license agreement with Radius Health, headquartered in Massachusetts, for the use of Eisai's new class of selective estrogen receptor modulator (SERM).

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