selective digestive decontamination

selective digestive decontamination (SDD)

The use of non-absorbable antibiotics to target potentially pathogenic organisms in the gut while leaving the normal anaerobic commensals unaffected. The purpose of SDD is to reduce the risk of transmitting dangerous infections to other patients in hospital. Antibiotics used include polymyxin B, tobramycin and amphotericin.
References in periodicals archive ?
Survival benefit of the full selective digestive decontamination regimen.
Mete-analyses of randomised controlled trials of selective digestive decontamination have clinical outcome measures, mainly pneumonia and mortality.
We use the search terms "intensive care unit", "critical care", "antibiotic combined therapeutic use", "antibiotic combined administration and dosages", "decontamination", "respiratory tract infection prevention and control", "bacterial infection", with the keywords "SDD", "selective decontamination", "selective digestive decontamination", "digestive decontamination", "bowel decontamination".
This systematic review of 54 randomised controlled trials assessing selective digestive decontamination in approximately 10,000 patients requiring intensive care is the most comprehensive to date.
Analysis of respiratory and non-respiratory infections in published trials of selective digestive decontamination. Intensive Care Med 2001; 27(Suppl 2):S285.
Can selective digestive decontamination avoid the endotoxemia and cytokine activation promoted by cardiopulmonary bypass?
Role of type of flow and protective effect of selective digestive decontamination. Intensive Care Med 1997; 23:1251-1257.
Prevention of nosocomial infection in a pediatric intensive care unit (PICU) through the use of selective digestive decontamination. Fur J Epidemiol 1998; 14:719-727.
Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients.
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