selective T-cell defect

selective T-cell defect

An autosomal recessive form (OMIM:176947) of severe combined immunodeficiency characterised by a selective absence of CD8-type T cells.

Molecular pathology
Caused by defects of ZAP70, which encodes a tyrosine kinase that plays a role in T-cell development and lymphocyte activation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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