selective immunoglobulin A deficiency

(redirected from Selective IgA deficiency)

se·lec·tive im·mu·no·glob·u·lin A de·fi·cien·cy

an inherited disorder in which IgA is markedly reduced or absent, resulting in immature IgA-bearing B cells.
References in periodicals archive ?
In addition, the serum tTg IgG and endomysial antibody IgG levels were measured in children with selective IgA deficiency. Tissue transglutaminase IgA, IgG, and endomysial antibody IgG (Euroimmun, Germany) were determined with micro enzyme-linked immunosorbent assay.
CVID is not commonly found in more than one member of a family, for about 10% of other first-degree relatives may be either hypogammaglobulinemic or may have selective IgA deficiency. So, IgA deficiency and CVID have been known to coexist in families.
Keywords: Sensorineural hearing loss, primary immunodeficiency, pediatric, selective IgA deficiency
Of all the inflammatory bowel diseases, UC is the one most frequently associated with selective IgA deficiency [7, 8].
In addition, autoimmunity findings may also be observed during the course of the disease in common variable immune deficiency (CVID), hyper IgM syndrome, X-linked agammaglobulinemia, selective IgA deficiency, CKGD, severe combined immune deficiencies, WAS, and complement deficiencies.
The most common primary immunodeficiency disorders include selective IgA deficiency --which affects 1 in 500 children--Ig[G.sub.2] deficiency, transient hypogammaglobulinemia of infancy, and DiGeorge anomaly, said Dr.
Yel, "Selective IgA deficiency," Journal of Clinical Immunology, vol.
Anti-tissue transglutaminase IgA assays which produce results with no detectable IgA antibody may be indicative of a patient with selective IgA deficiency, and these patients should be further investigated.
IgA is absent in selective IgA deficiency. Low levels of immunoglobulins with normal B lymphocyte numbers suggest CVID.
Autoimmune enteropathy is often found in patients with selective IgA deficiency, common variable immunodeficiency (CVID) and IPEX,3,4 but the role of NK cells remains undetermined.6,7 In our case report, patient initially presented with CD which was difficult to manage along with recurrent, opportunistic infections such as candidiasis and CMV disease.
Kalha and Sellin, however, argue that CVID is the second most common PID, second to selective IgA deficiency (4).
Conclusion: Selective IgA deficiency (SIgAD) was found in CD and in patients of other gastrointestinal complaints.
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