Keywords: Sensorineural hearing loss, primary immunodeficiency, pediatric, selective IgA deficiency
The most common primary immunodeficiency disorders include selective IgA deficiency
--which affects 1 in 500 children--Ig[G.
The most common diagnosis was selective IgA deficiency
Anti-tissue transglutaminase IgA assays which produce results with no detectable IgA antibody may be indicative of a patient with selective IgA deficiency
, and these patients should be further investigated.
Autoimmune enteropathy is often found in patients with selective IgA deficiency
, common variable immunodeficiency (CVID) and IPEX,3,4 but the role of NK cells remains undetermined.
A hypothesis was that CVID and selective IgA deficiency
syndrome may reflect a common underlying genetic defect because CVID and IgA-D both share clinical features (14), (15).
Kalha and Sellin, however, argue that CVID is the second most common PID, second to selective IgA deficiency
Conclusion: Selective IgA deficiency
(SIgAD) was found in CD and in patients of other gastrointestinal complaints.
However, CD is associated with selective IgA deficiency
Selective IgA deficiency
in children with recurrent parotitis of childhood.
De Laat PCJ, Weermaes CMR, Gonnera R et al Clinical manifestations in selective IgA deficiency
In studies by Gupta and Warren, it was found that 20% of children with autism had selective IgA deficiency