2006) Sulfated L selectin
ligands as a therapeutic target in chronic inflammation.
Fucoidan blocks actions of selectin
molecules that promote adhesion between cells and blood vessel walls.
In leukocyte adhesion deficiency syndrome (LAD), a genetic defect either in [beta]2 integrins (type I) or in fucosylated selectin
ligands (type II), leukocytes cannot stop or roll, respectively; this syndrome is characterized by marked leukocytosis and frequent bacterial infections.
KEY WORDS: Platelet receptors, Integrins, Selectins
is known to inhibit lymphocyte adhesion to the endothelium at a high enough concentration (Nielsen and Lyberg, 2004).
belongs to a family of structurally related selectin
E, P and L participate in endothelial leukocyte adhesion (1).
However each entry must have a different team name and a different selectin
Specifically, after systemic immunization the predominant homing receptor on antibody secreting cells is the L selectin
, after oral immunization the ad4bd7 integrin, and after nasal immunization a large portion expressed both the L selectin
and the ad4bd7 integrin.
9 In animal models, while active atherosclerotic plaques express increased levels P- Selectin
, fibrotic, inactive plaques do not express P- Selectin
Platelet microparticles and soluble P selectin
in peripheral artery disease: relationship to extent of disease and platelet activation markers.
ligands in extravasation of cancer cells and organ selectivity of metastasis.
Weekly biomarkers of inflammation included plasma interleukin-6, tumor necrosis factor-a soluble receptor II (sTNF-RII), soluble platelet selectin
), and C-reactive protein (CRP).