selected ion monitoring


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selected ion monitoring

A term defined in the context of mass spectrometry as the practice of monitoring and recording ion currents at one or more selected ion m/z values with time, rather than recording full mass spectra, as sample is introduced into the ion source. Because the detector is integrating signal for a longer time at the relevant ion, limits of detection can be lowered, at a cost of increased susceptibility of the analysis to unexpected interferences.
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[4] Nonstandard abbreviations: [T.sub.4], 3,3',5,5'-tetraiodo-L-thyronine, thyroxine; [T.sub.3], 3,3',5-triiodo-L-thyronine; rT3, 3',5',3-triiodothyronine or reverse [T.sub.3]; [FT.sub.4], free [T.sub.4]; [FT.sub.3], free [T.sub.3]; IA, immunoassay; ED, equilibrium dialysis; UF, ultrafiltration; ID-MS, isotope dilution mass spectrometry; GC, gas chromatography; SIM, selected ion monitoring; LC, liquid chromatography; MS/MS, tandem mass spectrometry; MRM, multiple reaction monitoring; IS, internal standard; SPE, solid-phase extraction; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; TSH, thyroid-stimulating hormone.
Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring. Biomed Environ Mass Spectrom 1989;18:471-7.
Determination of the nicotine metabolite trans-3'-hydroxycotinine in urine of smokers using gas chromatography with nitrogen-selective detection or selected ion monitoring. J Chromatogr 1992;583:145-54.
The structures of the compounds eluting from the HPLC were then confirmed using HPLC-MSM5, and the quantity of the MPA contaminating the MPAG sample was determined using HPLC-MS with selected ion monitoring (SI1VI), as described previously (8).
Detection was by massspectrum detector (1100 MSD; Hewlett-Packard) using selected ion monitoring in atmospheric pressure chemical ionization mode with positive polarity.
Determination of nicotine in serum and urine by isotope dilution using solid-phase extraction and gas chromatography/mass spectrometry with selected ion monitoring. Ann Clin Biochem 1998; 35:522-7.
The massselective detector was operated in the selected ion monitoring mode with mass ions monitored at a dwell time of 100 ms.

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