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There was no apparent interference from other compounds present in the sample because of the selectivity of selected ion monitoring.
Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: absence of an isotope effect in the clearance of (S)-nicotine-3',3'-[D.
5) Codeine, morphine, hydrocodone, and hydromorphone are separated without cross-interference and quantitated with deuterated internal standards and selected ion monitoring (SIM).

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