selamectin


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selamectin

(sel-ă-mek'tin),
An antiparasiticide member of the avermectin group, this semisynthetic veterinary drug is a modified version of doramectin; a macrocyclic lactone, this isolate results in the lowest toxicity in Collies; usually applied topically on a monthly basis, indications are for prevention of Dirofilaria immitis, Ctenocephalides felis, Sarcoptes scabeii, Dermacentro variabilis, Otodectes cynotis, and in cats, also Ancylostoma tubaeforme and Toxocara cati; commercial solution is flammable. Acts by enhancing gamma amino butyric acid release at the presynaptic membrane and enhancing chloride permeabilty, resulting in parasite paralysis and death. Not effective against flukes or tapeworms.
References in periodicals archive ?
Product Drug Application Fleas Ticks Activyl indoxacarb monthly spot-on [check] Advantage Imidacloprid, monthly spot-on [check] II pyriproxyfen Bravecto fluralaner every three months [check] [check] topical Capstar nitenpyram as-needed oral [check] Comfortis spinosad monthly oral [check] Effipro fipronil monthly spot-on [check] [check] Frontline fipronil monthly spot-on or [check] [check] spray Revolution selamectin monthly spot-on [check] Seresto synthetic eight-month collar [check] [check] pyrethroids, flumethrin, imidacloprid Vectra dinotefuran monthly spot-on [check]
Zoetis (http://www.zoetis.com) is giving cat owners a good reason to "tick the box" for parasite prevention with the launch of Revolution Plus (http://www.revolutionplus.com) (selamectin and sarolaner topical solution), a new topical product providing 6-in-1 pest protection against parasites common to cats and kittens of every lifestyle (indoor-only, indoor/outdoor, and outdoor-only).
Various drugs of Avermectin group includes Ivermectin, Abamectin, Doramectin, Eprinomectin and Selamectin can be used as acaricides to treat rabbits that are naturally infected with scabies (Kachhawa et al., 2013).
Traditional management of adult flea infestations on animals, during the past 15 y is by topical and oral applications of insecticides such as fipronil, imidacloprid, selamectin, and most recently by insect growth regulators (IGRs) such as lufenuron [2, 9, 11-16].
At this age, this bird had been dosed three times with a fipronil/methoprene combination (2 and 1mg) and three times with pour on selamectin (2mg).
According to the company, the active substances in Stronghold Plus are selamectin and sarolaner, a new combination of parasiticides.
Other drugs including Selamectin have shown to reduce the number of cat fleas [21].
Both cats were treated with spot-on solution containing 6% selamectin (Stronghold(R), Pfizer, Belgium) according to previous studies (Leone and Albanese, 2004; MartiOlle et al., 2011).
Two additional doses of ivermectin and 2 doses of topical selamectin (23 mg/kg) were administered 2 and 4 weeks apart, respectively.
Improved canine chemoprophylaxis may require combinations or sequential dosages of the macrocyclic lactones including ivermectin, moxidectin, selamectin, and milbemycin oxime; or by adding another effective antifilarial medication, such as melarsomine dihydrochloride to the prophylactic regimen.
REVOLUTION * Fleas * SELAMECTIN (two Do not administer