secretory component


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Related to secretory component: immunoglobulin M, secretory IgA

se·cre·to·ry com·po·nent

a polypeptide chain found in external secretions (for example, tears, saliva, colostrum) associated with immunoglobulins A and M. It also may occur in free form but when attached to dimeric IgA, it facilitates transport across the mucosal epithelial surface. The secretory piece is derived by proteolytic cleavage of the immunoglobulin receptor on epithelial cells.
References in periodicals archive ?
The band of H4JSC/H4L4J is composed of four IgA [alpha]-chains, J chain and secretory component or of four IgA [alpha]-chains, four [kappa]-chains, and J chain.
The cytoplasmic and transmembrane region of the receptor was proteolytically cleaved, the truncated receptor termed secretory component (SC) and released from the receptor together with dimeric IgA.
Corthesy, "Secretory component delays the conversion of secretory IgA into antigen- binding competent F(ab')2: a possible implication for mucosal defense," Journal of Immunology, vol.
Rolfe, "Binding of Clostridium difficile toxin A to human milk secretory component," Journal of Medical Microbiology, vol.
Cortheesy, "Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo," Immunity, vol.
Free secretory component from cystic fibrosis sputa displays the cystic fibrosis glycosylation phenotype.
Role of secretory IgA, secretory component, and eosinophils in mucosal inflammation.
Human milk contains large amounts of a protein called secretory component, notes Dallas.