Mammary analog secretory carcinoma
(MASC) was first described in 2010 as a rare salivary gland malignancy characterized by its similarities to breast secretory carcinoma
by histology, immunohistochemistry, and genetics.
17) Secretory carcinoma
is the most common primary breast cancer followed by intraductal cancer.
1%) case was reported as secretory carcinoma
and another one was diagnosed as encapsulated papillary carcinoma.
The trial demonstrated that entrectinib was well tolerated and positive responses were observed in non-small cell lung cancer (NSCLC), colorectal cancer, mammary analog secretory carcinoma
(MASC), melanoma and renal cell carcinoma.
Definition: Mammary analogue secretory carcinoma
(MASC) is a low-grade malignant tumor of salivary glands resembling secretory breast carcinoma, including histopathologic and immunohistochemical features and t(12;15)(p13;q25) translocation with ETV6-NTRK3 gene fusion.
Chrissy had breast cancer - a rare form called secretory carcinoma
, which affects one in a million women in the US.
These include commons SGTs such as mucoepidermoid carcinomas (MEC), adenoid cystic carcinoma (AdCC), and the newly described entity mammary analog secretory carcinoma
35] Of the 268 malignant lesions, most common diagnosis was infiltrating duct carcinoma (N = 229), followed by medullary carcinoma (N = 2) and mucinous carcinoma, infiltrating lobular carcinoma, sarcomatoid carcinoma, invasive papillary carcinoma, and secretory carcinoma
with one case each [Table 3].
Chrissy Turner noticed a lump on her chest and tests confirmed she had secretory carcinoma
Mammary analogue secretory carcinoma
(MASC) is one of the most recently described salivary gland tumors, first reported by Skalova et al (47) in 2010.
Doctors pinpointed the cancer as an invasive secretory carcinoma
, an extremely rare slow-moving variation of the disease.
In the past investigators have noticed histologic similarities between secretory carcinoma
of the breast and acinic cell carcinoma (AcCC) of both salivary gland and mammary origin, (1,2) and in 2008 it was found that AcCC of the breast lacked the ETV6 gene rearrangement found in secretory carcinoma
of the breast.