secretory IgA

secretory IgA

a dimer of class A immunoglobulins, the principal agents of mucosal immunity. IgA is the only immunoglobulin isotype that can pass through mucosal membranes to reach the lumen of internal organs.
References in periodicals archive ?
Our bodies have a built-in security system called secretory IgA, which is present in mucosal membranes that line the nose and upper respiratory tract.
These new zonulin ELISAs expand ALPCO's current gastrointestinal assay panel to investigate bile acids, calprotectin, alpha-1 antitrypsin, lysozyme, secretory IgA and pancreatic elastase.
IgM [sup]+ IgD [sup]hi (Mature) B lymphocytes related to the production of secretory IgA decreased in Peyer's patches.
IgA is produced by mucosal tissue as secretory IgA (SIgA) and also by plasma cells in bone marrow.
8)-(11) For acquired immunity at the mucosal epithelium, antigen-specific secretory IgA (SIgA) immune responses are key players in preventing pathogen invasion.
After a 2-week course of treatment, symptom resolution and normalization of antigliadin secretory IgA was found in 30/33 (91%) of patients.
The mucosal immune system improvs the adaptive anti-inflammatory defence to set homeostasis by immune exclusion mediated by secretory IgA antibodies to the clearance of pathogenic organisms from the mucosal surfaces by way of neutralising toxins and viral particles, inhibiting adherence of pathogens, colonisation and penetration of mucosal surfaces by pathogenic micro-organisms and immunosuppressive ways to limit over-reaction against inoffensive luminal antigens.
The general eukaryotic protein synthesis pathway is conserved between plants and animals, so plants can efficiently fold and assemble full-size serum immunoglobulins and secretory IgA.
Host-related factors such as sexual hormones, the presence of fibrin and fibrinogen, (2) and salivary compounds including mucine, (3) salivary proteins, (4) and secretory IgA (5) may also influence this process.
Recent studies suggest that secretory IgA concentrations during the day due to various factors such as diet, daily exercise and mood are different [34].
Effect of secretory IgA on the adherence of Streptococcus Mutans on human teeth