Hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome
, and resistance to cell death.
These func tions enhance the role of skeletal muscle as a vital secretory organ.13 Muscle secretome
has also been analysed by induction of contraction in the skeletal muscle myotubes through electric pulse stimulation (EPS).
Citation: Kshitiz et al., Dynamic secretome
of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail.
Therefore, senescence of MSCs may have a great impact on body's health given that it can alters the composition of their secretome
and can impair the key MSC biological functions (3, 4, 14).
Characterisation of the Bordetella pertussis secretome
under different media.
This reinforces the view of this amphibian species as a profitable reservoir of bioactive compounds, highlighting the need to sample more specimens to expand the current, and still restricted, knowledge about its skin secretome
Identification of human exercise-induced myokines using secretome
Analysis of protein expression (secretome
) by human and mouse preimplantation embryos.
Proteomic analysis of the secretome
of Leishmania donovani.
Liu et al., Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome
. Stem Cell Research & Therapy, 2018 9:268, 24 October 2018
[9-11] After their activation, they release products which are either synthesized or secreted which constitutes "platelet secretome
." Platelet secretome
includes proteins and polysaccharides that are stored in processed or precursor forms and can be released rapidly; [12-15] whereas, others are products that are triggered when platelets themselves receive activating signals.
Quantitative iTRAQ secretome
analysis of Aspergillus niger reveals novel hydrolytic enzymes.