sup] revealed that NETs formation in an equine model of recurrent airway obstruction was significantly reduced in a time- and concentration-dependent manner by secretoglobin family 1A member 1 (SCGB 1A1), a small protein primarily secreted by mucosal epithelial cells of the lungs.
Secretoglobin 1A1 and 1A1A differentially regulate neutrophil reactive oxygen species production, phagocytosis and extracellular trap formation.
Genes such as EpCAM, cadherin 1_1 (CDH1_1), secretoglobin
family 2A member 1 (SCGB2A1)/MAM, estrogen receptor 1 (ESR1), epithelial membrane protein 2 (EMP2), and KRT19 were exclusively expressed in CTCs, while protein tyrosine phosphatase, receptor type C (PTPRC; formerly called CD45) and vimentin (VIM) were predominant in the leukocytes.
Both the lipocalin and the secretoglobin
family are very complex.
showed that a panel of 6 genes was superior to EpCAM and secretoglobin
, family 2A, member 2 (SCGB2A2, also known as mammaglobin and hMAM) for the detection of CTCs in breast cancer, and that theses genes may serve as potential markers for CTC derived from endometrial, cervical, and ovarian cancers as well (40).
5] Human genes: ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (also known as HER2); KRT19, keratin 19 (also known as CK19); SCGB2A2, secretoglobin
, family 2A, member 2 (also known as MGB1, mammaglobin A); EPCAM, epithelial cell adhesion molecule; MUC1, mucin 1, cell surface associated; TWIST1, twist homolog 1 (Drosophila); MAGEA3, melanoma antigen family A, 3; HMBS, hydroxymethylbilane synthase (also known as PBGD).
The crystal structure of the major eat allergen Fel d 1, a member of the secretoglobin