GHRL is a potent growth hormone secretagogue
, which is mainly produced by endocrine cells of the gastric oxyntic mucosa and linked to many physiological and pathophysiological aspects, such as bone metabolism, in addition to growth.
The company's cardiorenal portfolio includes the Phase 3 development of tenapanor for the treatment of hyperphosphatemia in people with end-stage renal disease who are on dialysis, and RDX013, a potassium secretagogue
Metformin plus an insulin secretagogue
was the most frequently used drug combination (40%, n=176), followed by metformin plus dipeptidyl peptidase-4 inhibitors (DDP-4 inh) (28%, n=124).
The growth hormone production in response to growth hormone secretagogue
is suppressed by growth hormone releasing hormone antagonist11.
Participants were divided into three groups by treatment modality: group 1, insulin sensitizers (metformin or thiazolidinediones); group 2, insulin secretagogues
(sulfonylureas or glinides); and group 3, one insulin secretagogue
in combination with one insulin sensitizer.
Resection of the posterior nasal nerve involved suppression of the secretagogue
motor and the inhibition of neurogenic inflammation induced by parasympathetic and sensory denervation demonstrated by biopsy of the inferior turbinate 3-4 months after surgery .
Muccioli, "Cortistatin, but not somatostatin, binds to growth hormone secretagogue
(GHS) receptors of human pituitary gland," Journal of Endocrinological Investigation, vol.
It is the natural ligand of the growth hormone secretagogue
(a substance eliciting release of another substance) receptor, and elicits the release of growth hormone (GH) from the pituitary (Shintani et al.
There are some secretagogue
agents currently under investigation by pharmaceutical companies.
Ghrelin is a gut/brain peptide comprising 28 amino acids and is originally identified as the endogenous ligand of the growth hormone secretagogue
receptor (GHSR) (1, 2).
If the patient is currently taking an insulin secretagogue
or insulin when an SGLT2 is added, consider lowering the dose of the insulin secretagogue
or insulin to avoid hypoglycemia.
Ghrelin is an endogenous ligand for the growth hormone secretagogue