secondary failure

sec·on·dar·y fail·ure

1. failure of the function of an organ as a result of antecedent pathology elsewhere;
2. decreasing responsiveness to a drug after an initial satisfactory response, usually occurring several months after initiation of treatment.

sec·on·dar·y fail·ure

(sekŏn-dar-ē fālyŭr)
1. Failure of function of an organ as a result of antecedent pathology elsewhere.
2. Decreasing responsiveness to a drug after an initial satisfactory response, usually occurring several months after initiation of treatment.
References in periodicals archive ?
Over subseguent years, he was on adalimumab monotherapy for 3 years, which was discontinued following secondary failure. This was promptly followed by ustekinumab for 9 months but had to be discontinued because of primary inefficacy.Then, he was then on infliximab for a year, which again had to be terminated following an inadeguate response and a possible infusion reaction.
Secondary failure rates of measles vaccines: a metaanalysis of published studies.
And, the secondary failure cracks propagating from the main joint tips occur in different degrees.
These products offer a promising alternative mechanism of action for diabetes treatment and may be considered as an add-on therapy or if secondary failure occurs with other products.
It can be found that the number of secondary failure nodes has a significant reduction when the constraint condition of node bearing capacity is relaxed.
Ineffectiveness of an oral drug may be termed as primary failure (no history of response to the drug), secondary failure (lack of response after an initial period of euglycaemia), or non-response (this term is used for newer classes of drugs, in preference to 'failure').
Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
Secondary failure was defined as inflammatory relapse after previous control of inflammation.
The failure of the firewalls separating different parts of the platform, a secondary failure since they were never designed to cope with an explosion, ignited the oil stores.
Testosterone deficiency can result from defects in testicular production of androgens (primary testicular failure), at the hypothalamic-pituitary level (secondary failure), or from combined mechanisms.
The failure of the firewalls separating different parts of the facility, a secondary failure since they were never designed to cope with an explosion, ignited the oil stores.
When circuit A is lost, the total load on circuit B is 16 amps, which will not cause a secondary failure. To provide power redundancy for critical systems, the power capacity at the rack level will need to be at least two times the amount of power consumed by these devices.