Familial Mediterranean fever is one of the leading causes of secondary amyloidosis
is not a rare event in patients not adequately treated or noncompliant patients.
If colchicine treatment is provided within reasonable time, the accumulation of amyloid protein in the tissue can be impeded and secondary amyloidosis prevented or reversed (dependent on the severity).
This medication should be taken daily to decrease episode frequency and severity and to prevent or reverse secondary amyloidosis that has developed.
In addition, a dramatic decrease in secondary amyloidosis, the most serious complication of FMF, has been reported in Turkey in recent years.
(3) Thus, a lack of awareness of a population for FMF would lead to an increased rate of secondary amyloidosis.
Several studies on amyloidosis, totaling 351 patients, failed to include a single patient with malignant lymphoma. Amyloidosis has been described in lymphoplasmacytoid lymphoma and other non-Hodgkin lymphoma at various sites, such as lung, salivary gland, gastrointestinal tract, gall bladder, conjunctiva, and cerebrum. In several reports on MALT lymphoma, we found only a few cases of secondary amyloidosis
, none of them involving the breast.[4,5,9,10] The amyloid deposits and plasma cell differentiation were restricted to the sites of chronic alimentary antigenic stimulation, which suggests a possible role of immune mechanisms in the pathogenesis of amyloidosis in MALT lymphoma.[9,10]
Secondary amyloidosis occurs with a wide range of predisposing or co-existent pathology like chronic infection-tuberculosis, inflammatory condition--rheumatoid arthritis cystic fibrosis, bronchiectasis, and Crohn's disease, Chronic renal failure, Multiple myeloma (4,5).
In a review by Levillain et al., 56% of cases of amyloid goiter were caused by secondary amyloidosis (6).
It was reported that the proinflammatory cytokine TNF-a could be involved in the pathogenesis of secondary amyloidosis
. The treatment with infliximab was demonstrated to be effective in the resolution of proteinuria resulting from renal amyloidosis in a patient with rheumatoid arthritis. Metyas et al. reported a case with renal amyloidosis secondary to FMF who was successfully treated with anti-TNF therapy.
She was then was referred to nephrology department and secondary amyloidosis was detected in her left kidney after biopsy.
In our case presence of homozygote M694V gene mutation and secondary amyloidosis was presented.