Pre-treatment prediction of chemoresistance in second-line chemotherapy
of ovarian carcinoma: value of serological tumor marker determination (tetranectin, YKL-40, CASA, CA 125).
(10-17) For patients who receive second-line chemotherapy
, an analysis of data from the TROPIC trial identified nine prognostic variables: Eastern Cooperative Oncology Group (ECOG) performance status, presence of pain, measurable disease, presence of visceral disease, time since last docetaxel use, duration of hormonal use, hemoglobin, PSA, and ALP.
Patients who are candidates for HDT/ASCR should be treated with second-line chemotherapy
like dexamethasone, cisplatin, cytarabine (DHAP), ifosfamide, carboplatin, etoposide (ICE), or methylprednisolone, etoposide, cytarabine, cisplatin with or without rituximab.
The donation will be used to support a wide spectrum of cancer care, including the costs of first-line and second-line chemotherapy
and radiotherapy, surgical procedures, and also help in paying for medications, prosthetic limbs and medical equipment for patients.
The patient was qualified for the second-line chemotherapy
consisting of ifosfamide 5 g/[m.sup.2] i.v.
The patient underwent 8 courses of second-line chemotherapy
using gemcitabine (1,000 mg/[m.sup.2], days 1, 8, and 15) and paclitaxel (180 mg/[m.sup.2], day 1) (GP-chemotherapy #1-8, Table S1) .
Bichevet al., "Survival advantage for irinotecan versus best supportive care as second-line chemotherapy
in gastric cancer--a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)," European Journal of Cancer, vol.
With regard to second-line chemotherapy
, there were fewer patients of the AFP [greater than or equal to] 20 ng/ml group who received second-line chemotherapy
than the AFP < 20 ng/ml group (40.0% versus 53.0%, P = 0.055).
The second-line chemotherapy
options include pemetrexed (if not administered first line), vinorelbine, or gemcitabine.
Therefore, patients with elevated tumor marker levels after first-line chemotherapy should receive second-line chemotherapy
before surgery, as in our cases .
with pemetrexed platinum doublet is frequently administered when no actionable mutation is identified or if biopsy was not feasible.