secobarbital


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Related to secobarbital: Seconal

secobarbital

 [sek″o-bahr´bĭ-tal]
a short-acting barbiturate used as the sodium salt as a sedative and hypnotic, particularly as a presurgical aid to anesthesia, and as an anticonvulsant in the treament of tetanus.

secobarbital

(sĕk′ō-bär′bĭ-tôl′, -tăl′)
n.
A white odorless barbiturate, C12H18N2O3, used in the form of its sodium salt as a sedative and hypnotic.

secobarbital

Neuropharmacology An intermediate-acting sedative and hyponotic, replaced by benzodiazepines Adverse effects Prolonged drowsiness, parodoxic excitement, diffuse arthritis, myalgic, or neuralgic pain, hypersensitivity in Pts with upregulated immunity–eg, with asthma, angioedema, urticaria, drug interactions–eg, MAOIs, INH, ethanol; stimulation of hepatic microsomal enzymes may ↑ metabolism of drugs, endogenous steroids, and certain anesthetics Pharmacologic effects Like phenobarbital Used for Anxiolytic, relieves insomnia; pre-anesthesia
References in periodicals archive ?
David initially proposed that a phenobarbital sedative dose of 60 mg be substituted for each "hypnotic" dose (100 mg in the case of secobarbital or pentobarbital).
The AAP (2001) lists the following analgesics as maternal medications usually compatible with breastfeeding: acetaminophen (Tylenol[R], Tempra[R] paracetamol), codeine (Empirin[R] #3 #4, Tylenol[R] #3 #4), fentanyl (Sublimaze[R]), ibuprofen (Advil[R], Nuprin[R], Motrin[R], Pediaprofen[R]), ketorolac (Toradol[R], Acular[R]), meperidine (Demerol[R]), methadone (Dolophine[R]), morphine (Duramorph[R], Infumorph[R]), naproxen (Anaprox[R], Naprosyn[R], Aleve[R]), and secobarbital (Seconal[R]).
* (D) twenty of the patients were prescribed nine grams of secobarbital or penobarbital combined with a number of non lethal prescriptions to be used in conjunction with the lethal medication; (200)
The short-acting and intermediate-acting barbiturates, such as secobarbital and pentobarbital, are used for induction of general anesthesia.
(Nembutal) Downers, Nembies, Yellow jackets, Yellow submarine Secobarbital (Seconal) Bullets, Pink ladies.
Codeine S/P ratios were more variable than those of methaqualone, secobarbital, and diphenhydramine.
Immunoassay screening was performed on all urine specimens using the following tests, cutoff values, and reference substances: amphetamines (d-methamphetamine, 1000 [micro]g/L); barbiturates (secobarbital, 200 [micro]g/L); benzodiazepines (nordazepam, 100 [micro]g/L); cannabis (11-nor-[Delta]-9-THCCOOH, 50 [micro]g/L); cocaine (benzoylecgonine, 300 [micro]g/L); methadone (300 [micro]g/L); methaqualone (300 [micro]g/L); tricyclic antidepressants (nortriptyline, 300 [micro]g/L); and D-lysergic acid diethylamide (LSD, 0.5 [micro]g/L).
Detection limit, mg/L Drug UV 254 nm [Cl.sub.2] HCI HgS[O.sub.4] Acetaminophen 0.50 2.5 NR NR Caffeine 0.10 NR NR NR Carbamazepine 0.20 0.02 0.04 NR Carisoprodol NR NR NR 1.0 Nordiazepam 0.10 0.05 0.1 NR Theophylline 0.20 NR NR NR Secobarbital NR NR NR 0.2 NR, no obvious reaction with the reagent indicated.
Barbiturates (phenobarbital, butobarbital, and secobarbital), meprobamate, antidepressant agents (amitriptyline, nortriptyline, imipramine, and clomipramine), phenothiazines (acepromazine, alimemazine, and cyamemazine), and benzodiazepines (diazepam, bromazepam, flunitrazepam, clonazepam, alprazolam, nitrazepam, nordazepam, and prazepam) were extracted from 5 mL of serum, 20 mL of urine, or 20 mL of gastric lavage fluid by Tox-Elut[R] from Varian (Harbor City, CA).
(Our in-house control contained only butalbital and secobarbital.) Our logs for recording controls were too simple, excluding the compounds and their retention times.