scrotal cancer

scrotal cancer

an epidermoid malignancy of the scrotum, characterized initially by a small sore that may ulcerate. The lesion occurs most frequently in elderly men who have been exposed to soot, pitch, crude oil, mineral oils, polycyclic hydrocarbons, or arsenic fumes from copper smelting. Treatment involves wide surgical excision of the tumor and resection of inguinal nodes. In the eighteenth century Sir Percival Pott associated scrotal cancer in chimney sweeps with exposure to soot. It was the first malignancy shown to be caused by an environmental carcinogen. Also called chimney-sweeps' cancer, soot wart.
References in periodicals archive ?
Weinberg begins the story of how tumors occur from the first cell with the story of Percival Pott who studied scrotal cancer in chimney sweeps in England in 1775.
For example, in the 18th century, Sir Percival Pott stopped an epidemic of scrotal cancer in chimney sweeps by asking them to improve their genital hygiene (Pott 1775), while knowing little about the cause, biology or mechanism of this disease.
About 230 years ago, the English surgeon Percivall Pott noted a higher frequency of scrotal cancer among chimney sweeps, and concluded that there was something carcinogenic in soot.
One scrotal cancer is recorded at a mind-boggling seven feet in circumference and two feet round its neck.
The ability of certain PAH compounds and PAH mixtures to induce cancers has been the subject of research since the original observation by Pott of increased scrotal cancer incidence among chimney sweeps in 1775, and the first induction of skin tumours in rabbits by dermal application of coal tar for 150 days.
A mortality analysis of workers in many occupations indicated an increased risk of scrotal cancer for creosote-exposed brickmakers (18,34-38).
Approximately 10,000 women are diagnosed with cervical cancer, 2160 women are diagnosed with vaginal, 2000 women are diagnosed with vulvar, 1400 men are diagnosed with anal, 1100 men are diagnosed with penile, and 500 men are diagnosed with scrotal cancers each year.
They are also a recognised cause of occupational skin and scrotal cancers.
While in an advice centre he found leaflets linking the oils with skin and scrotal cancers.
Settlements have been made in the past for former Rover workers who suffered scrotal cancers believed to have been caused by carcinogenic oils used in heavy manufacturing until the 1970s.
In 18th century England, the high incidence of scrotal cancers noted among chimney sweeps led the enactment of protective regulations requiring these workers to bathe.
Sir Percival Potts observed an apparent association between scrotal cancers and tar and soot exposures among chimney sweeps in London in 1775 (Harrison 2004).