The researchers found no evidence that screening had an effect on morbidity or mortality or on the effectiveness of treatment of screen-detected
Known hypertension was defined as individuals who were diagnosed as hypertensive and currently on medication, and screen-detected
hypertension as BP [greater than or equal to] 140/90 mmHg.
It cited five potential harms: death or complications from a biopsy of a screen-detected
nodule, surgery for a screen-detected
lesion that turns out to be benign, the psychosocial impact of finding a lung nodule, over diagnosis and the cumulative radiation exposure from a serial low-dose chest CT scans.
"A small screen-detected
tumor can be easily excised by a breast surgeon with minimal side effects and relatively little or no additional treatment depending on the patient's desires, the cancer's biology, and the woman's general health," she observes.
Yet 35% of screen-detected
breast cancers could be "ultra low risk" with less than a 5% chance of progression in two decades.
Breast cancer genetic risk profile is differentially associated with interval and screen-detected
Ductal carcinoma in situ (DCIS) makes up approximately 20% of all screen-detected
ABI is low in perhaps about 6% of adults over 40 years old but "the natural history of screen-detected
PAD, including the development of morbidity and mortality directly related to atherosclerosis in the lower limbs, is not well known....
What remains missing from the literature is a qualitative exploration of the impact of being diagnosed with screen-detected
Does training of general practitioners for intensive treatment of people with screen-detected
diabetes have a spillover effect on mortality and cardiovascular morbidity in 'at risk' individuals with normoglycaemia?
(7) Masked cancers are often only discovered because of a lump after a normal screening mammogram, as so-called "interval cancers." Compared with screen-detected
cancers, interval cancers tend to be more biologically aggressive, to have spread to lymph nodes, and to have worse prognoses.
No good-quality studies assessed the net benefit of thyroid cancer screening, nor whether "early" treatment of screen-detected
cancers improved patient outcomes.