scrapie


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scrap·ie

(skrap'ē, skrā'pē),
A communicable spongiform encephalopathy of the central nervous system of sheep and goats caused by a prion and characterized by a very long incubation period followed by pruritus, abnormalities of gait, and invariably death; it resembles Creutzfeldt-Jakob disease and kuru in humans.
[from scraping by affected animals against objects to relieve itching]

scrapie

(skrā′pē, skrăp′ē)
n.
A fatal neurodegenerative disease of sheep and goats caused by a prion and marked by chronic itching and loss of muscular coordination.
A prion-induced infection, which causes fatal neurologic degeneration in sheep and goats, who scrape themselves on rocks and other surrogate back-scratchers; the scrapie agents are transmissible spongiform encephalopathy agents, which integrate themselves into the cell membrane, possibly as replicable glycoproteins

scrap·ie

(skrā'pē)
A communicable spongiform encephalopathy of the central nervous system of sheep and goats caused by a prion; resembles Creutzfeldt-Jakob disease and kuru in humans.
[from scraping against objects by affected animals to relieve itching]

scrapie

A fatal nervous system disease of sheep featuring a SPONGIFORM ENCEPHALOPATHY. Scrapie is caused by a PRION and has an incubation period of 2 to 7 years.

scrapie

a disease of sheep, thought to be caused by PRIONS, in which the animal develops intense itching and increasing weakness, and eventually dies.
References in periodicals archive ?
RML scientists injected either ASO1 or ASO2 into mice 14 days prior to infecting them with scrapie, and then seven or 15 weeks after infection.
There are other tests that link scrapie, CJD, and CWD to prions and not bacteria, but who knows?
In animals, disorders resembling sporadic or genetic human prion diseases have been reported only recently, with the discovery of atypical/Nor98 scrapie in small ruminants (7) and L- and H-type BSE in cattle (8,9).
Los haplotipos ARR y ARQ son considerados de resistencia y AHQ de resistencia intermedia, mientras que VRQ es un haplotipo de susceptibilidad para el scrapie (Baylis y Goldmann, 2004).
Eight mouse-passaged scrapie strains were analyzed for strain-specific differences in secondary structure [93].
Schonberger et al., "Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes," Biochemistry, vol.
The good news is that a new, live-animal test to detect scrapie is being applied to goats.
Later, despite much collaborative work in other laboratories, there remained uncertainty on the role and composition of scrapie associated fibres.
The natural incidence of scrapie varies among animals indicating that the genotype of the host plays a role in modulating susceptibility to the disease (8).
The normal form of the protein is called [PrP.sup.C] (C is for cellular), whereas the infectious form is called [PrP.sup.Sc] (Sc is for scrapie).
In the cattle brain disease BSE, its human equivalent vCJD, and the sheep disease scrapie, the infectious agents are thought to be rogue prion proteins.
Scrapie was the first transmissible spongiform encephalopathy described, with reports going back to the 18th century.