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an anticholinergic and antimuscarinic alkaloid derived from various plants, having a depressant effect on the central nervous system. Used as an antisialagogue preanesthetic medication and as an adjunct to general anesthesia, administered parenterally; as an antiemetic, administered orally or parenterally; and as a cycloplegic and mydriatic, applied topically to the conjunctiva. Called also hyoscine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

scopolamine (hyoscine (UK))

Scopoderm TTS (UK), Transderm-Scop, Transderm-V (CA)

scopolamine hydrobromide (hyoscine hydrobromide)

Buscopan (UK), Kwells (UK)

Pharmacologic class: Antimuscarinic, belladonna alkaloid

Therapeutic class: Antiemetic, antivertigo agent, anticholinergic

Pregnancy risk category C


Acts as competitive inhibitor at postganglionic muscarinic receptor sites of parasympathetic nervous system and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. May block cholinergic transmission from vestibular nuclei to higher CNS centers and from reticular formation to vomiting center.


Injection: 1 mg/ml in 1-ml vials, 0.4 mg/ml in 0.5-ml ampules and 1-ml vials, 0.86 mg/ml in 0.5-ml ampules

Transdermal system (Transderm-Scop): 1.5 mg/patch (releases 0.5 mg scopolamine over 3 days)

Indications and dosages

Preanesthetic sedation and obstetric amnesia

Adults: 0.3 to 0.6 mg I.M., I.V., or subcutaneously 45 to 60 minutes before anesthesia, usually given with analgesics

Postoperative nausea and vomiting

Adults: One transdermal patch placed behind ear on evening before surgery and kept in place for 24 hours after surgery. For cesarean section, one transdermal patch placed behind ear 1 hour before surgery.

Motion sickness

Adults: One transdermal patch placed behind ear 4 hours before anticipated need, replaced q 3 days if needed


• Hypersensitivity to scopolamine, other belladonna alkaloids, or barbiturates

• Hypersensitivity to bromides (injection only)

• Angle-closure glaucoma

• Acute hemorrhage

• Myasthenia gravis

• Obstructive uropathy (including prostatic hypertrophy)

• Obstructive GI disease (including paralytic ileus and intestinal atony)

• Reflux esophagitis

• Ulcerative colitis or toxic megacolon

• Hepatic or renal impairment

• Chronic lung disease (with repeated doses)


Use cautiously in:

• suspected intestinal obstruction; pulmonary or cardiac disease; tachyarrhythmia or tachycardia; open-angle glaucoma; autonomic neuropathy; hypertension; hyperthyroidism; ileostomy or colostomy

• history of seizures or psychosis

• elderly patients

• pregnant or breastfeeding patients (safety not established)

• children.


• For I.V. use, give by direct injection at prescribed rate after diluting with sterile water.

• After removing protective strip from transdermal patch, avoid finger contact with exposed adhesive layer to prevent contamination.

Adverse reactions

CNS: drowsiness, dizziness, confusion, restlessness, fatigue

CV: tachycardia, palpitations, hypotension, transient heart rate changes

EENT: blurred vision, mydriasis, photophobia, conjunctivitis

GI: constipation, dry mouth

GU: urinary hesitancy or retention

Skin: decreased sweating, rash


Drug-drug. Antidepressants, antihistamines, disopyramide, quinidine: additive anticholinergic effects

Antidepressants, antihistamines, opioid analgesics, sedative-hypnotics: additive CNS depression

Oral drugs: altered absorption of these drugs

Wax-matrix potassium tablets: increased GI mucosal lesions

Drug-herbs. Angel's trumpet, jimsonweed, scopolia: increased anticholinergic effects

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess vital signs and neurologic, cardiovascular, and respiratory status.

• Monitor patient for urinary hesitancy or retention.

Patient teaching

• Tell patient transdermal patch is most effective if applied to dry skin behind ear 4 hours before traveling.

• Caution patient to avoid touching exposed adhesive layer of transdermal patch.

• Advise patient to wash and dry hands thoroughly before and after applying patch.

• If patch becomes dislodged, instruct patient to remove it and apply new patch on a different site behind ear.

• Tell patient that using patch for more than 72 hours may cause withdrawal symptoms (headache, nausea, vomiting, dizziness). Advise him to limit use when feasible.

• Inform patient that his eyes may be markedly sensitive to light during patch use. Instruct him to wear sunglasses and use other measures to guard eyes from light.

• Caution patient to avoid alcohol because it may increase CNS depression.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


(skō-pol'ă-mēn, -min),
An alkaloid found in the leaves and seeds of Hyoscyamus niger, Duboisia myoproides, Scopolia japonica, S. carniolica, Atropa belladonna, and other solanaceous plants; exerts anticholinergic actions similar to that of atropine, but is thought to have greater central nervous system effects; useful in preventing motion sickness; available as various salts.
Synonym(s): hyoscine
Farlex Partner Medical Dictionary © Farlex 2012


(skə-pŏl′ə-mēn′, -mĭn)
An alkaloid drug, C17H21NO4, extracted from plants such as henbane and used primarily to treat motion sickness and nausea and to dilate the pupil. Also called hyoscine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


®Therapeutics An atropine-like anticholinergic–or antimuscarinic, used in preanesthesia, where CNS depression is desirable, GI tract antispasmodic, to ↑ heart rate, and counteract vasodilation and low BP caused by choline esters Metabolism GI tract absorption,12 metabolized in liver, remainder in kidneys Adverse efects Dry mouth, tachycardia, palpitation, pupillary dilatation, blurring of vision, headache, dry
hot skin
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


An alkaloid found in the leaves and seeds of Hyoscyamus niger, and other solanaceous plants; exerts anticholinergic actions similar to that of atropine, but thought to have greater central nervous system effects; useful in preventing motion sickness; available as various salts.
Synonym(s): hyoscine.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


An ATROPINE-like drug used in premedication as a sedative and to dry up respiratory and salivary secretions.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


(skō-pol'ă-mēn, -min)
An alkaloid found in the leaves and seeds of various plants; exerts anticholinergic actions similar to that of atropine, but is thought to have greater central nervous system effects; useful in preventing motion sickness.
Synonym(s): hyoscine.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Scopolamine is a potent anticholinergic drug which impairs memory by blocking cholinergic neurotransmission in certain brain parts.
M1 and M2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine. J Pharmacol Exp Ther 2014; 351: 448-56.
Group VI received extract with most nootropic activity (50 mg/kg) for 7 days when 90 min of extract treated, scopolamine (HCL (0.4 mg/kg) was given.
"Unofficial estimates put the number of annual scopolamine incidents in Colombia at approximately 50,000," according to the warning.
Before memory impairment with scopolamine, ovariectomized rats (OVX) had a significantly higher (p < 0.001) number of entries into the arms of the Y-maze than normal rats (SHAM 2).
Afterwards, animals received combined pharmacological treatments with an interval of 30 min between both injections (group 1: vehicle + vehicle; group 2: donepezil + vehicle; group 3: vehicle + scopolamine; and group 4: donepezil + scopolamine).
In addition, the company's transderm scop (scopolamine 1.5 mg) transdermal system patch is an anticholinergic indicated for the prevention of nausea and vomiting associated with motion sickness and recovery from anesthesia after surgery in adults.
Molecular and cellular mechanisms of rapid-acting antidepressants ketamine and scopolamine. Curr Neuropharmacol.
(109) Scopolamine is an anticholinergic agent which has in the put forth as an attractive amnesic agent for discerning the action of antimnesic drugs that are under investigation.
This study aimed to investigate the effects of the prophylactic administration of pinaverium bromide before colonoscopy and the effects of pinaverium bromide alone at different time points or combined with scopolamine butylbromide.
Analyzes of the secondary metabolites scopolamine and hyoscyamine carried out on Datura stramonium on the same plots show that the average hyoscyamine (HS) content is higher than that of scopolamine (SC) with 0.723 [+ or -] 0.11 mg [g .sup.-1] and 0.277 [+ or -] 0.04 mg.[g.sup.-1] MS [41], this rate of production of these alkaloids depends on several environmental factors, stage of plant, development and edaphic conditions, and environmental humidity [26, 7, 18], in particular phytophagous insects which are selection agents on these alkaloids [51].