sclerotome


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sclerotome

 [skle´ro-tōm]
1. an instrument used in incision of the sclera.
2. the area of a bone innervated from a single spinal segment.
3. one of the paired masses of mesenchymal tissue, separated from the ventromedial part of a somite, which develop into vertebrae and ribs.

scle·ro·tome

(sklē'rō-tōm),
1. A knife used in sclerotomy.
2. The group of mesenchymal cells emerging from the ventromedial part of a somite and migrating toward the notochord. Sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae.
[sclero- + G. tomē, a cutting]

scle·ro·tome

(skler'ō-tōm)
1. A knife used in sclerotomy.
2. The group of mesenchymal cells emerging from the ventromedial part of a mesodermic somite and migrating toward the notochord. Sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae.
[sclero- + G. tomē, a cutting]
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References in periodicals archive ?
Shh also promotes sclerotome formation while inhibiting dermatome formation [23].
Current Progress and Challenges for Skeletal Muscle Differentiation from Human Pluripotent Stem Cells Using Transgene-Free Approaches
McCredie, "Melorheostosis and the sclerotomes: a radiological correlation," Skeletal Radiology, vol.
A Unique Case of Melorheostosis Presenting with Two Radiologically Distinct Lesions in the Shoulder
The knockdowns of Fbxl18, Tgfb2, and Tle3 showed clear sclerotome defects thus providing evidence for their role in skeletal under the control of the Sox trio enhancers.
An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos
Patterning of mammalian somites by the surface ectoderm and the notochord: Evidence for sclerotome induction by Sonic hedgehog/Vhh-1.
Immunolocalization of Morphogen Sonic Hedgehog in Salmon Fry (Salmo salar)/Inmunolocalizacion del Morfogeno Sonic Hedhehog en Alevines de Salmon (Salmo salar)
The polar bodies probably are derived from the sclerotome. The anterior trabeculae are formed from neural crest tissue, and they make up a portion of the visceral skeleton anterior to the mandibular gill arch.
Phylogeny and embryology of the facial nerve and related structures. Part I: phylogeny
Atlanto-occipital assimilation is failure of segmentation between the fourth occipital sclerotome and the first spinal sclerotome.[17]
Chiari I Malformation: Clinical Presentation and Management
Dermomyotome also serves as a tissue for secreted signaling molecules to the neural tube, notochord, and sclerotome [13, 14].
Skeletal Muscle Cell Induction from Pluripotent Stem Cells
reptiles) the cranial half of the first cervical sclerotome remains as a separate bone, 'the proatlas', between the occiput and atlas vertebra.
Study of variations of occipital condyles
Vertebrae are derived from the sclerotome portions of the somites, which are derived from paraxial mesoderm.
A study of sacrum with five pairs of sacral foramina in western India
The somites are divided into three parts: Ventromedial sclerotome; Intermediate myotome; and Lateral dermatome.
Study of atlanto-axial fusion--[C1 and C2 vertebral synostosis] among 200 atlas vertebrae
The abnormal area is usually along a specific sclerotome. The second and third digits of the hands and feet are most frequently involved, corresponding to the median nerve and medial plantar nerve supply in the upper and lower limbs, respectively.
Macrodystrophia-giant thumb
Dorsally, somites differentiate into epithelial dermomyotome, which then develops into myotome (the source of limb muscle), into dermatome (a specific region for nerve reception supplied by sensory neurons), and ventrally into mesenchymal sclerotome. The nuclei of myofibers originate from the myotomal somitic or lateral plate somatic mesoderm depending on the anatomical tissue location [31].
Intrinsic ability of adult stem cell in skeletal muscle: an effective and replenishable resource to the establishment of pluripotent stem cells

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