sclerotome


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sclerotome

 [skle´ro-tōm]
1. an instrument used in incision of the sclera.
2. the area of a bone innervated from a single spinal segment.
3. one of the paired masses of mesenchymal tissue, separated from the ventromedial part of a somite, which develop into vertebrae and ribs.

scle·ro·tome

(sklē'rō-tōm),
1. A knife used in sclerotomy.
2. The group of mesenchymal cells emerging from the ventromedial part of a somite and migrating toward the notochord. Sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae.
[sclero- + G. tomē, a cutting]

scle·ro·tome

(skler'ō-tōm)
1. A knife used in sclerotomy.
2. The group of mesenchymal cells emerging from the ventromedial part of a mesodermic somite and migrating toward the notochord. Sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae.
[sclero- + G. tomē, a cutting]
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References in periodicals archive ?
McCredie, "Melorheostosis and the sclerotomes: a radiological correlation," Skeletal Radiology, vol.
The knockdowns of Fbxl18, Tgfb2, and Tle3 showed clear sclerotome defects thus providing evidence for their role in skeletal under the control of the Sox trio enhancers.
Patterning of mammalian somites by the surface ectoderm and the notochord: Evidence for sclerotome induction by Sonic hedgehog/Vhh-1.
The polar bodies probably are derived from the sclerotome. The anterior trabeculae are formed from neural crest tissue, and they make up a portion of the visceral skeleton anterior to the mandibular gill arch.
Atlanto-occipital assimilation is failure of segmentation between the fourth occipital sclerotome and the first spinal sclerotome.[17]
Dermomyotome also serves as a tissue for secreted signaling molecules to the neural tube, notochord, and sclerotome [13, 14].
reptiles) the cranial half of the first cervical sclerotome remains as a separate bone, 'the proatlas', between the occiput and atlas vertebra.
Vertebrae are derived from the sclerotome portions of the somites, which are derived from paraxial mesoderm.
The somites are divided into three parts: Ventromedial sclerotome; Intermediate myotome; and Lateral dermatome.
The abnormal area is usually along a specific sclerotome. The second and third digits of the hands and feet are most frequently involved, corresponding to the median nerve and medial plantar nerve supply in the upper and lower limbs, respectively.
Dorsally, somites differentiate into epithelial dermomyotome, which then develops into myotome (the source of limb muscle), into dermatome (a specific region for nerve reception supplied by sensory neurons), and ventrally into mesenchymal sclerotome. The nuclei of myofibers originate from the myotomal somitic or lateral plate somatic mesoderm depending on the anatomical tissue location [31].