Body composition was measured using a BCA (seca mBCA515, Germany) with the BIA method; the indices used included total AT, the visceral fat index (VFI), sclerotin, protein, skeletal muscle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW).
Elements of the body frame, including sclerotin (3.45 [+ or -] 0.58 kg versus 3.05 [+ or -] 0.42 kg, p = 0.001), protein (11.06[+ or -]2.26kg versus 9.49[+ or -] 1.64kg, p = 0.001) and the skeletal muscle mass (36.23[+ or -] 7.40kg versus 30.79 [+ or -] 5.33 kg, p = 0.001), were significantly larger in the patients with acromegaly.
In the female acromegaly patients, although TBW (p = 0.039), ECW (p = 0.009), sclerotin (p = 0.041), protein (p = 0.040), and skeletal muscle (p = 0.024) were larger than those in the female controls, total AT did not decrease, the AT distribution did not change, and TEE and BM did not increase.
The sclerotin and skeletal muscle mass decreased during the postoperative period in the patients with acromegaly.
The sclerotin, protein, skeletal muscle, TEE, and BM were higher in the acromegaly patients preoperatively and declined after surgery.
This finding might be the comprehensive outcome of decreased body fat and increased sclerotin and skeletal muscle.
While it was originally considered a benign lesion, recent studies11 suggest that this tumor occurs commonly, typically at the distal femur and proximal tibia around the knee joints; it has aggressive features, and it is considered a potentially malignant tumor that could destroy the sclerotin
around the knee joint and affect knee function.