Sclerosing perineurioma is an extraneural soft tissue perineurioma variant first described by Fetsch and Miettinen, (6) who reported 19 tumors, all arising in the hands, mainly of young male adults.
The differential diagnosis for sclerosing perineurioma mainly includes fibroma of tendon sheath, epithelioid glomus tumor, epithelioid sarcoma (Table), and highly collagenized examples of giant cell tumor of tendon sheath.
Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults.
(49,67) Recent studies have shown that chromosome 10q rearrangements or deletions seem to be a recurrent abnormality in sclerosing perineuriomas. (7) An isolated case of ESTP with loss of the chromosome 13 has also been reported.