Sclerosing epithelioid fibrosarcoma of the pancreas.
A, Sclerosing epithelioid fibrosarcoma shows cytologically atypical cells in the background of collagenized stroma.
14) Lack of epithelial markers and conspicuous S100 expression with aforementioned histopathologic features are helpful in differentiating an OFMT from a sclerosing epithelioid fibrosarcoma
and a synovial sarcoma; the latter displays focal, rather than diffuse, S100 expression.
Other more-rare entities that differ in treatment but morphologically resemble ILC and may involve the breast include metastases of signet ring carcinomas from other primary sites, sclerosing epithelioid fibrosarcoma, myeloid sarcoma, mucosa-associated lymphoid tissue lymphoma, and plasma cell dyscrasias.
Sclerosing epithelioid fibrosarcoma also resembles, and should be included in the differential diagnosis of, ILC, especially when cytokeratin and ER IHC stain results are negative.
Differential diagnostic entities to consider include IDC-L, metastatic signet ring cell carcinomas, sclerosing epithelioid fibrosarcoma, and primary or secondary leukemic or lymphomatous involvement of the breast.
FUS rearrangements are rare in 'pure' sclerosing epithelioid fibrosarcoma.
MUC4 is a useful marker for low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma (SEF; Figure 5).
Sclerosing epithelioid fibrosarcoma, another fibroblastic neoplasm, shows morphologic and molecular overlap with LGFMS, and hybrid tumors showing features of both exist.
Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases.
Recurrent EWSR1-CREB3L1 gene fusions in sclerosing epithelioid fibrosarcoma.
Primary sclerosing epithelioid fibrosarcoma
of the sacrum: a case report and review of the literature.