sclerosing adenosis


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scle·ros·ing ad·e·no·sis

a nodular, benign breast lesion occurring most frequently in relatively young women and consisting of hyperplastic distorted lobules of acinar tissue with increased collagenous stroma; the changes may be difficult to distinguish microscopically from carcinoma. Additionally, a benign nodular microscopic lesion of the prostate consisting of acinar tissue with increased stroma; the basal cell layer shows characteristic smooth muscle metaplasia.
Farlex Partner Medical Dictionary © Farlex 2012

scle·ros·ing ad·e·no·sis

(sklĕ-rō'sing ad'ĕ-nō'sis)
1. A nodular, benign breast lesion occurring most frequently in relatively young women and consisting of hyperplastic distorted lobules of acinar tissue with increased collagenous stroma; the changes may be difficult to distinguish microscopically from carcinoma.
2. A benign nodular microscopic lesion of the prostate consisting of acinar tissue with increased stroma; the basal cell layer shows characteristic smooth muscle metaplasia.
Synonym(s): adenofibrosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
In this study, 3 cases contained pseudoangiomatous stromal hyperplasia (12.5%), and two cases (8.3%) were found to have both sclerosing adenosis and adenosis.
The distribution of solid masses according to sex and age groups Age range (years) Solid masses 0-2 2-8 8-15 >15 Female Fibroadenoma (a) - - 2 7 9 Tubular adenoma - - 1 1 2 Probably benign mass (b) 1 - 7 10 18 Hemangioma 5 - 1 - 6 Peripheral papilloma - - - - 1 Hamartoma - - - 1 1 Nodular sclerosing adenosis (c) - - - 1 1 Fibroadenomatous hyperplasia - - - 2 2 Lipoma - - 1 1 - Total 6 0 12 23 40 Solid masses Male n (%) Fibroadenoma (a) - 9 (22) Tubular adenoma - 2 (5) Probably benign mass (b) - 18 (43) Hemangioma - 6 (14) Peripheral papilloma - 1 (2) Hamartoma - 1 (2) Nodular sclerosing adenosis (c) - 1 (2) Fibroadenomatous hyperplasia - 2 (5) Lipoma 2 2 (5) Total 2 42 (100) (a) Biopsy yielded seven classic and two juvenile fibroadenomas.
Some of these entities include radial scar, sclerosing adenosis, fibroadenoma, fat necrosis, and pseudoangiomatous stromal hyperplasia.
The areas of abnormal enhancement had been sampled in 2011, and at that time, pathology results had revealed sclerosing adenosis.
Specific benign and malignant lesions Pathological diagnosis n Benign lesions (N = 98) Atypical ductal hyperplasia 1 Phyllodes 1 Ductal ectasia 2 Lipoid necrosis 2 Ductal hyperplasia 8 Fibroadenoma 14 Sclerosing adenosis 20 Fibrocystic change 50 Malignant lesions (N = 4) Ductal carcinoma in situ 3 Invasive lobular carcinoma 1 Table 3.
Sclerosing adenosis is a benign condition of the breast in which extra tissue develops within the breast lobules.
AIDH and IDH are asymptomatic lesions that are detected incidentally on mammography or in the resection specimens of other lesions (fibrocystic change, sclerosing adenosis, fibroadenoma etc.) [7].
(5) Diagnostic results can be false positive due to misinterpretation of lobular cancerization and sclerosing adenosis. False negative results can be due to masking of the foci of disease by inflammatory cells or falsely identifying tumor cells as histiocytes.
Furthermore, FISH analysis is only as good as the cells that are analyzed, and identifying the invasive tumor cells can be challenging, given the presence of confounding elements (e.g., ductal carcinoma in situ, sclerosing adenosis), tumor heterogeneity, and the fact that FISH is performed in a dark room under ultraviolet light.
Microscopically there was a non-encapsulated lesion with a combination of stroma and cells in the terminal duct lobular units and there was superimposed sclerosing adenosis indicative of a hamartoma.
Some of these calcifications may be the result of radiation-induced sclerosing adenosis, a benign process in which fibrotic changes compress glandular tissue causing multiple calcifications.
Histopathologic criteria for JP are as follows: duct papillomatosis, apocrine and non-apocrine cysts, papillary apocrine hyperplasia, sclerosing adenosis, and duct stasis.