Specific benign and malignant lesions Pathological diagnosis n Benign lesions (N = 98) Atypical ductal hyperplasia 1 Phyllodes 1 Ductal ectasia 2 Lipoid necrosis 2 Ductal hyperplasia 8 Fibroadenoma 14 Sclerosing adenosis
20 Fibrocystic change 50 Malignant lesions (N = 4) Ductal carcinoma in situ 3 Invasive lobular carcinoma 1 Table 3.
2-10) Pathologic examination of a radial scar often reveals a diverse array of pathologic findings including typical epithelial hyperplasia, sclerosing adenosis
, papillomatosis, atypical epithelial hyperplasia, ductal carcinoma in situ (DCIS), and early stage invasive carcinomas.
Sclerosing adenosis is a benign condition of the breast in which extra tissue develops within the breast lobules.
When is a diagnosis of sclerosing adenosis acceptable at core biopsy?
of the prostate gland: a clinicopathological and immunohistochemical study of 11 cases.
3 (a) 0 Subsequent MDH FDH ADH ALH Calcs SA FA Cancer Status No cancer 6 3 3 1 27 32 3 Cancer 0 0 1 0 1 3 2 Abbreviations: ADH, atypical ductal hyperplasia; ALH, atypical lobular hyperplasia; Calcs, calcifications; DH, ductal hyperplasia; FA, fibroadenoma; FDH, florid ductal hyperplasia; MDH, moderate ductal hyperplasia; SA, sclerosing adenosis
In breast tissues, the contractile protein SMA has been demonstrated in the normal MEC in 88% to 100% of cases, (19,33,34) in normal luminal/epithelial cells in 37% of cases, (34) and in the MEC associated with benign lesions (such as sclerosing adenosis
and radial scars) in 95.
4) In a study that focused on TURP chips, cases misinterpreted as adenocarcinoma included atypical adenomatous hyperplasia (26% of the false-positive cases), basal cell hyperplasia (26%), atrophy (16%), sclerosing adenosis
(10%), high-grade prostatic intraepithelial neoplasia (10%), xanthogranulomatous prostatitis (6%), florid cribriform hyperplasia (3%), and postatrophic hyperplasia (3%).
The size and cytologic criteria proposed by O'Malley et al (4,5) do not distinguish intraductal apocrine proliferations from those arising in/ associated with sclerosing adenosis
It is well documented that there is an overlap in diagnostic features and supportive clues between prostatic adenocarcinoma and some benign small acinar proliferations, most notably atypical adenomatous hyperplasia, sclerosing adenosis
, and postatrophic hyperplasia.
2] False-positive diagnosis of MICB may be due to misinterpretation of lobular cancerization, radial sclerosing lesion, sclerosing adenosis
, and fibrosing entrapment of epithelium; its false-negative diagnosis may be due either to masking of the invasive focus by inflammatory cells on lower magnification (Figure, A) or mistaking of tumor cells for histiocytes on higher magnification (Figure, B).
A case showing sclerosing adenosis
and an unusual form of basal cell hyperplasia of the prostate.