mature within 4-6 weeks inside the portal vein, mate, and migrate to their destination, which is either the perivesicular or mesenteric venous plexus, to start the cycle again (Fig.
Group 1: Uninfected native control, Groups 2-6: S mansoni infected mice and classified as follow: Group 2: S mansoni-infected animals (positive control), Group 3: infected-N sativa treated group immediately at the time of infection (immature schistosomula < 14 days post infection).
The best result was obtained in groups 3 and 4 in wwhich sativa seeds are eitheradministered at the time of infection, G3 (in the presence of immature larvae, schistosomula) or ten days after infection, G4 (during schistosomula maturation).
The current study demonstrated that administration of N sativa crushed seeds to mice harboring S mansoni have shown potential antischistosomal activity against the different developmental stages of thee parasites, immature larveae (schistosomula, < 14 days Pi, G3), during schistosomula maturation (14-21 days PI,G4), at the time of schistosomula maturation (>21days PI,G5) and after the beginning of egg laying (>35 days PI,G6) (Davies et al.
At present, praziquantel (PZQ) is the only drug recommended for the treatment and control of schistosomiasis, although it is not active against schistosomula and young worms and does not prevent reinfection (Sabah et al.
Treatment was started on the 1st, 14th, 28th and 45th day after infection to evaluate the following stages of development: skin schistosomula, lung schistosomula, young worms (stages before oviposition) and adult worms (stage after oviposition) (Fig.
mansoni--skin schistosomule (1 day after infection), lung schistosomula (14 days after infection), young worms (28 days after infection) and adult worms (45 days after infection), significantly reduced (p< 0.