schistocyte


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Related to schistocyte: target cell, microspherocyte, burr cell

schistocyte

 [shis´-, skis´to-sīt]
a fragment of an erythrocyte, commonly observed in the blood in hemolytic anemia; called also helmet cell and schizocyte.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

schis·to·cyte

(skis'tō-sīt),
A variety of poikilocyte that owes its abnormal shape to fragmentation occurring as the cell flows through damaged small vessels.
Synonym(s): schizocyte
[schisto- + G. kytos, cell]
Farlex Partner Medical Dictionary © Farlex 2012

schistocyte

(shĭs′tə-sīt′)
n.
A red blood cell having an abnormal shape as a result of fragmentation that occurs as the cell flows through damaged small vessels.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

schistocyte

A fragmented red cell which arises from either an intrinsic increase in cell fragility or due to intravascular rugosities that traumatise cells; schistocytes are a nonspecific finding seen in hemolysis, trauma, prosthetic heart valves, megaloblastic and microangiopathic anaemioccidianhemolytic uremic syndrome, TTP.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ker·a·to·cyte

(ker'ă-tō-sīt)
1. The fibroblastic stromal cell of the cornea.
2. A variety of poikilocyte that owes its abnormal shape to fragmentation occurring as the cell flows through damaged small vessels.
Synonym(s): schistocyte.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

schistocyte

(skis'to-sit) [? + kytos, cell]
Enlarge picture
SCHISTOCYTE: In peripheral blood (×600)
A fragmented red blood cell that appears in the blood in a variety of bizarre shapes, from small triangular forms to round cells with irregular surfaces. Schistocytes are found in patients with hemolytic anemias, severe burns, and several other conditions. Synonym: schizocyte See: illustration
illustration
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Automated detection and classification of schistocytes by a novel red blood cell module using digital imaging/ microscopy.
The highest rate of misclassification occurred with dacrocytes and acanthocytes, both of which were predominantly misclassified as schistocytes (Table 2).
The diagnosis of TTP was distinguished from haemolytic anaemia related to her CTD by means of the profuse presence of schistocytes on peripheral smear, normal complement levels and negative Coombs test.
A minimum of 10 fields were observed by 2 Pathologists and a presence of more than 1 percent schistocytes were reported as diagnostic.
However, the absence of schistocytes on the peripheral smear along with the normal haptoglobin pointed away from this diagnosis.
MAHA results from intravascular fragmentation of red blood cells, which produces schistocytes on peripheral blood smear.
Even if no schistocytes were found on repeated peripheral blood smears, TMA remained our main hypothesis with suspicion of an unusual spleen-localized presentation.
Serum markers of TA-TMA include elevated lactate dehydrogenase, de novo thrombocytopenia not explained by other post-HSCT complications, Coombs test-negative hemolytic anemia (often hallmarked by increased free plasma hemoglobin and decreased haptoglobin), peripheral schistocytes, and signs of renal dysfunction (proteinuria and elevated creatinine).
Hematological markers demonstrated HCT-TMA with thrombocytopenia, elevated lactate dehydrogenase, and schistocytes.
The initial labs showed anaemia (Hb=7.1g/dl) and thrombocytopenia (plt=84*10^9/L) with 7% schistocytes on peripheral smear.
Peripheral blood films in these cases revealed hypochromia and microcytosis, target cells and schistocytes and pencil cells in those with iron deficiency complicating beta thalassemia trait.
Schistocytes were not appreciated on the peripheral smear.