Inflammatory cells are subsequently recruited to the arterial wall, such as monocytes, which differentiate into macrophages and are, as a result, activated to engulf oxidized LDL via scavenger receptors
, creating foam cells, which secrete chemokines and other kinds of cytokines that further create a vicious cycle, more immune cell infiltration, and activation .
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LDLR: low-density lipoprotein receptor; SCARB: scavenger receptor
B; HMGCR: HMG-CoA reductase; CETP: cholesteryl ester transfer protein.
Association of three polymorphisms of scavenger receptor
class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tunisian population.
CD163 is an Hb scavenger receptor
exclusively expressed in the cell's monocyte/macrophage system.
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Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor
distinct from the macrophage scavenger receptor