Several types of targeting probes, such as monoclonal antibodies, their proteolytic and engineered fragments, and scaffold proteins
, were evaluated for imaging of HER2 .
PDZD7 is a scaffold protein
containing three PDZ domains, a HNL domain, and a PR region.
PDZK1, a scaffold protein
, contains four PDZ-banding domains generally comprising 80-90 amino acids, which play crucial roles in targeting proteins to specific cell membranes, assembling proteins into signaling complexes for efficient transduction, and regulating the functions of transmembrane proteins .
Several studies supported that TRB3 may function as a scaffold protein
to control MAPK activity [10, 16, 17].
Wang, "The scaffold protein
Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons," Journal of Neuroscience, vol.
It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein
LAT) are not randomly distributed within the plasma membrane thus giving rise to lateral organization which affects signalling efficiency.
Prior to Amgen, Hayes served as vice president and Venture Leader of Centyrex, a biotech Venture within Janssen R and D, focused on the development of small alternative scaffold proteins
Both IGF signaling and insulin require scaffold proteins
that are the key regulators of many signaling pathways.
Furthermore, high-titer platform technologies for new antibody mimetic formats such as scaffold proteins
and antibody fragments are available for the manufacture of customer products.
Furthermore, scaffold proteins
have to be present at the right time and location to ensure proper transmitter release.
Ubhi et al., "Progressive accumulation of amyloid-[beta] oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
," FEBS Journal, vol.
It is possible to develop even smaller targeting probes by using engineered nonimmunoglobulin scaffold proteins
, which can be 2- to 4-fold smaller than VHH fragments.