scaffold protein


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A multivalent protein that coordinates the location of enzymes in close proximity to specific substrates. Scaffold proteins are structurally and functionally linked to macromolecule assembly, and follow ordered pathways, accomplished by switching proteins through discrete conformations as they’re incorporated into a growing molecular complex

scaffold protein

(skaf′ōld″)
A protein that links other proteins so they can jointly perform some biochemical function.
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References in periodicals archive ?
Several types of targeting probes, such as monoclonal antibodies, their proteolytic and engineered fragments, and scaffold proteins, were evaluated for imaging of HER2 [9].
Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors
PDZD7 is a scaffold protein containing three PDZ domains, a HNL domain, and a PR region.
Identification of Binding Partners of Deafness-Related Protein PDZD7
PDZK1, a scaffold protein, contains four PDZ-banding domains generally comprising 80-90 amino acids, which play crucial roles in targeting proteins to specific cell membranes, assembling proteins into signaling complexes for efficient transduction, and regulating the functions of transmembrane proteins [10].
Upregulation of PDZK1 by Calculus Bovis Sativus May Play an Important Role in Restoring Biliary Transport Function in Intrahepatic Cholestasis
Several studies supported that TRB3 may function as a scaffold protein to control MAPK activity [10, 16, 17].
Tribbles 3 regulates the fibrosis cytokine TGF-[beta]1 through ERK1/2-MAPK signaling pathway in diabetic nephropathy
Wang, "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons," Journal of Neuroscience, vol.
Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond
It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein LAT) are not randomly distributed within the plasma membrane thus giving rise to lateral organization which affects signalling efficiency.
MEMREGPRO: How Membrane Physical Properties and Cortical Actin Regulate Protein Interactions During T Cell Signalling
Prior to Amgen, Hayes served as vice president and Venture Leader of Centyrex, a biotech Venture within Janssen R and D, focused on the development of small alternative scaffold proteins.
Immusoft Names Hayes as Chief Scientific Officer
Both IGF signaling and insulin require scaffold proteins that are the key regulators of many signaling pathways.
Metadichol - A Breakthrough in Diabetes Treatment
Furthermore, high-titer platform technologies for new antibody mimetic formats such as scaffold proteins and antibody fragments are available for the manufacture of customer products.
Boehringer Ingelheim Biopharmaceuticals GmbH
Furthermore, scaffold proteins have to be present at the right time and location to ensure proper transmitter release.
Germany : Presynapses come in a packet
Ubhi et al., "Progressive accumulation of amyloid-[beta] oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins," FEBS Journal, vol.
Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease
It is possible to develop even smaller targeting probes by using engineered nonimmunoglobulin scaffold proteins [8], which can be 2- to 4-fold smaller than VHH fragments.
Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with [sup.64]Cu Using NOTA and NODAGA

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