We hypothesized that satratoxin G (SG)-albumin adducts may serve as biomarkers of exposure to this fungus.
KEY WORDS: biomarkers, satratoxin G, Stachybotrys chartarum, trichothecenes.
In an experiment with mice, the chemical, satratoxin, targeted neurons running from the inside of the nose to the brain's smell center.
This is the first demonstration that a neuron can be killed by satratoxin," notes Jack R.
Vascular-system effects (including vascular fragility and hemorrhaging in tissues or from the lungs) are associated with aflatoxin, satratoxin
, and roridins.
Samples contained the potent protein synthesis inhibitor Satratoxin H, a member of the Trichothecene mycotoxin group that causes immunosuppression.
who practices occupational medicine at Mount Sinai Medical Center in New York, demonstrated that mycotoxins from workers exposed to high levels of Satratoxin in buildings contaminated with Stachybotrys can cause pathogenic effects.
This novel test detects trichothecene mycotoxins--including satratoxin
(G & H), roridin A, roridin L-2, verrucarol and verrucarin A produced by Stachybotrys and other toxic molds.
The Michigan team found that a single low dose of satratoxin
G administered directly into the noses of mice selectively killed sensory neurons involved in detecting odors and sending signals to the olfactory bulbs in the brain.
G (SG) is a macrocyclic trichothecene mycotoxin produced by Stachybotrys chartarum, the "black mold" suggested to contribute etiologically to illnesses associated with water-damaged buildings.
chartarum or from closely related fungi (atranones B and E, satratoxin
G, trichodermin, 7-[alpha]-hydroxytrichodermol, staplabin, and SMTP-7) and the known fungal toxins sterigmatocystin, citrinin, and ochratoxin A were each tested with Str.
The complex trichothecenes, satratoxin
and roridin, produced by Stachybotrys chartarum, were found in minute quantities.