sarcosine dehydrogenase

sar·co·sine de·hy·dro·gen·ase

[MIM*604455]
an enzyme that cleaves sarcosine using some acceptor to produce glycine, formaldehyde, and a reduced acceptor molecule; a deficiency of this enzyme will result in sarcosinemia.
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By conversion of choline to betaine by betaine aldehyde dehydrogenase and choline dehydrogenase [11], the three methyl groups of choline are readily available for three different conversions: (1) sarcosine into glycine by sarcosine dehydrogenase enzyme, (2) by using betaine from betaine-homocysteine methyltransferase as methyl donor and converting homocysteine into methionine, and (3) in conversion of dimethylglycine into sarcosine by dimethylglycine dehydrogenase enzyme.
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review
Sarcosine in the presence of an enzyme, Sarcosine dehydrogenase is converted into glycine, while another enzyme, Glycine - N- methyl transferase generates Sarcosine by degradation of glycine.
SYNTHESIS AND CHARACTERIZATION OF MIXED LIGAND COMPLEXES OFCOBALT WITH 1,10- PHENANTHROLINE AND SARCOSINE
DMG is converted into sarcosine and sarcosine is converted into glycine by two oxidative demethylation steps mediated by DMG dehydrogenase (DMGDH; EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1), respectively.
Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study

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