sarcosine dehydrogenase

sar·co·sine de·hy·dro·gen·ase

[MIM*604455]
an enzyme that cleaves sarcosine using some acceptor to produce glycine, formaldehyde, and a reduced acceptor molecule; a deficiency of this enzyme will result in sarcosinemia.
References in periodicals archive ?
By conversion of choline to betaine by betaine aldehyde dehydrogenase and choline dehydrogenase [11], the three methyl groups of choline are readily available for three different conversions: (1) sarcosine into glycine by sarcosine dehydrogenase enzyme, (2) by using betaine from betaine-homocysteine methyltransferase as methyl donor and converting homocysteine into methionine, and (3) in conversion of dimethylglycine into sarcosine by dimethylglycine dehydrogenase enzyme.
Sarcosine in the presence of an enzyme, Sarcosine dehydrogenase is converted into glycine, while another enzyme, Glycine - N- methyl transferase generates Sarcosine by degradation of glycine.
DMG is converted into sarcosine and sarcosine is converted into glycine by two oxidative demethylation steps mediated by DMG dehydrogenase (DMGDH; EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1), respectively.