levels in serum/plasma of male control patients were found to be in the range of 1.
The metabolomic analysis yielded the observation that sarcosine
was highly associated with tumour development.
was undetectable in healthy tissue but turned up in large amounts in cancers confined to the prostate gland and in even greater amounts in metastatic cancers, which had spread beyond the gland.
Researchers might also be able to inhibit prostate cancer's spread by designing drugs that manipulate the sarcosine
This test was designed as a powerful tool for better understanding of metastatic cancers as it identifies elevated levels of sarcosine
, shown to be indicative of aggressive cancers of the prostate.
Cobalamin, betaine, dimethylglycine, sarcosine
, total homocysteine, total cysteine, tryptophan, ADMA, SDMA, creatinine, and methylmalonic acid were essentially stable under all conditions.
INCI name: Sodium cocoyl amino acids, sarcosine
, potassium aspartate, magnesium aspartate Use levels: 3% Applications: Skin care Comments: Soothing agent suitable for after sun that provides complete protection from external aggressions and a sensorial experience of well being.
Solidified plugs were deproteinated with sodium lauryl sarcosine
and proteinase K, and then washed repeatedly.
The results of the study, conducted with researchers at the University of Michigan, will be published in the February 12 issue of Nature in a paper titled "Metabolomic profiles delineate potential role for sarcosine
in prostate cancer progression".
The StatSensor (Nova Biomedical) handheld creatinine device uses capillary flow of whole blood into a test strip impregnated with creatinine amidohydrolase, creatine aminohydrolase, sarcosine
oxidase, and peroxidase which oxidize ferric-cyanide to ferrous-cyanide, producing a current ([e.
5 M EDTA, 1% N-lauroyl sarcosine
, 1mg/mL proteinase K) followed by incubation at 55[degrees]C overnight.
This method is based on the same reaction sequence as the Creatinine-PAP (phenol aminophenazone) method (29) consisting of 4 consecutive enzymatic steps via creatininase, creatinase, sarcosine
oxidase, and peroxidase, but using a different chromophore (2,4,6-triiodo-3-hydroxybenzoic acid) and a modified detergent composition.