saralasin


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saralasin

 [sar-al´ah-sin]
an angiotensin II antagonist, used in the form of the acetate ester as an antihypertensive in treatment of severe hypertension and in diagnosis of renin-dependent hypertension.
References in periodicals archive ?
Fischer, "Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells," Journal of Cellular Physiology, vol.
Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer
Addition of saralasin (Ang II antagonist), however, could inhibit hCG-induced oocyte maturation (3).
The effect of media supplementation with angiotensin on developmental competence of ovine embryos derived from vitrified-warmed oocytes
In theca cells, there was no difference in mRNA expression for CYP17A1, HSD3B2 and STAR between dominant follicles treated with saralasin or vehicle during follicular deviation (FERREIRA et al., 2011a).
Experiment 3 was conducted to investigate if Ang II role on bovine theca cells steroidogenesis cells is affected in the presence of an Ang II receptors antagonist (saralasin).
Additionally, it was observed a significant decrease in mRNA abundance for the enzyme CYP19A1 in granulosa cells of dominant follicles after intrafollicular injection of saralasin (FERREIRA et al., 2011a).
Indeed, the intrafollicular injection of saralasin in the dominant follicle did not reduce CYP17A1 expression, which is in agreement with findings in the present study showing that Ang II do not increase CYP17A1 mRNA expression in LH-treated cells.
(2011a) in bovine theca cells treat with saralasin. However, variances in the experimental conditions, such as the reproductive status and metabolism of the cows used for cell collection, might have accounted for the nonhomogenous findings.
Steroidogenic enzymes mRNA expression profile and steroids production in bovine theca cells cultured in vitro and stimulated with angiotensin II/Perfil de expressao de RNAm de enzimas esteroidogenicas e producao de esteroides a partir de celulas da teca bovina cultivadas in vitro e estimuladas por Angiotensina II
The standard reference compound was saralasin, which was tested in each experiment at several concentrations to obtain a competition curve from which its IC50 was calculated.
Melinjo (Gnetum gnemon I.) seed extract decreases serum uric acid levels in nonobese Japanese males: a randomized controlled study
The activation of the TF was reversed by saralasin, an antagonist of angiotensin II receptors.
Lessons from a crab: molecular mechanisms in different memory phases of Chasmagnathus
Furthermore, hCG-induced oocyte maturation was inhibited by a concomitant addition of saralasin (an Ang II antagonist) (3)
The effect of angiotensin on the quality of in vitro produced (IVP) sheep embryos and expression of [Na.sup.+]/[K.sup.+]/ATPase
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