saralasin


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saralasin

 [sar-al´ah-sin]
an angiotensin II antagonist, used in the form of the acetate ester as an antihypertensive in treatment of severe hypertension and in diagnosis of renin-dependent hypertension.
References in periodicals archive ?
Fischer, "Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells," Journal of Cellular Physiology, vol.
Addition of saralasin (Ang II antagonist), however, could inhibit hCG-induced oocyte maturation (3).
In theca cells, there was no difference in mRNA expression for CYP17A1, HSD3B2 and STAR between dominant follicles treated with saralasin or vehicle during follicular deviation (FERREIRA et al., 2011a).
Experiment 3 was conducted to investigate if Ang II role on bovine theca cells steroidogenesis cells is affected in the presence of an Ang II receptors antagonist (saralasin).
Additionally, it was observed a significant decrease in mRNA abundance for the enzyme CYP19A1 in granulosa cells of dominant follicles after intrafollicular injection of saralasin (FERREIRA et al., 2011a).
Indeed, the intrafollicular injection of saralasin in the dominant follicle did not reduce CYP17A1 expression, which is in agreement with findings in the present study showing that Ang II do not increase CYP17A1 mRNA expression in LH-treated cells.
(2011a) in bovine theca cells treat with saralasin. However, variances in the experimental conditions, such as the reproductive status and metabolism of the cows used for cell collection, might have accounted for the nonhomogenous findings.
The standard reference compound was saralasin, which was tested in each experiment at several concentrations to obtain a competition curve from which its IC50 was calculated.
The activation of the TF was reversed by saralasin, an antagonist of angiotensin II receptors.
Furthermore, hCG-induced oocyte maturation was inhibited by a concomitant addition of saralasin (an Ang II antagonist) (3)