saquinavir


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Related to saquinavir: ritonavir, nelfinavir, Saquinavir mesylate

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

saquinavir

/sa·quin·a·vir/ (sah-kwin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the base or the mesylate salt in treatment of HIV infection and AIDS.

saquinavir

(sə-kwĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its mesylate, used usually in combination with other drugs to suppress the replication of HIV.

saquinavir

an antiviral.
indications It is used to treat HIV in combination with zidovudine and zalcitabine.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects of this drug include buccal mucosa ulceration, headache, musculoskeletal pain, asthenia, and hyperglycemia. Common side effects are diarrhea, abdominal pain, nausea, paresthesia, and rash.

saquinavir

A PROTEASE INHIBITOR drug used in conjunction with other anti-HIV drugs to treat AIDS. Saquinavir acts by blocking the enzyme aspartic protease, so preventing the cleavage of gag and gag-pol polyproteins into functional proteins. The result is the production of immature and non-infectious viral particles. The drug is on the WHO official list. A brand name is Invirase.
References in periodicals archive ?
CYP3A5genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir.
John's Wort Primidone Sulfinpyrazone Weak/moderate Nefazodone Quinidine inhibitors Nevirapine Ranitidine Norfloxacin Sertindole Norfluoxetine Troleandomycin Omeprazole Verapamil Paroxetine Zafirlukast Propoxyphene Zileuton Strong inhibitors * Ketoconazole Ritonavir Nelfinavir Saquinavir * Requires dosage modification when used in combination with PDE5 inhibitor.
The FDA approves new formulation of saquinavir (Fortovase, a soft-gel formulation designed to improve absorption in the body).
Simultaneous determination of the HIV-protease inhibitors indinavir, nelfnavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography.
On simvastatin and on saquinavir, for example, one proprietary product includes grapefruit among the interactions but another one does not.
When using saquinavir as part of an anti-viral regimen, fortovase is the recommended formulation.
Volunteers received 1200 milligrams of saquinavir for three 4-day periods and garlic supplements along with the saquinavir during the second period.
saquinavir (Fortovase, Invirase) levodopa (Atamet, Larodopa) Treats Parkinson's Disease.
Delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Fortovase), and efavirenz (Sustiva) may increase ergot levels resulting in ergotism (nausea, vomiting, and vasospastic ischemia).
The drugs in this class include: indinavir (Crixivan[R]), saquinavir mesylate (Invirase[R]), nelfinavir mesylate (Viracept[R]), ritonavir (Norvir[R]), saquinavir (Fortovase[R]), and amprenavir (Agenerase[R]).
Concomitant antiretroviral agents used with NVP for PEP included zidovudine and lamivudine [10]; stavudine and lamivudine (three); zidovudine and didanosine (two); stavudine and didanosine (one); stavudine and indinavir (one); didanosine and indinavir (one); stavudine, didanosine, and ritonavir (one); lamivudine, didanosine, and nelfinavir (one); stavudine, lamivudine, nelfinavir, and saquinavir (one); and none (one).
Examples of protease inhibitors already in use include saquinavir, nelfmavir, and indinavir.