sample size adjustment

sample size adjustment

In a clinical trial, an interim assessment of blinded data to validate sample size calculations or reevaluate the sample size.
References in periodicals archive ?
This study, known by the acronym VALOR, has an innovative, adaptive design that allows for a one-time sample size adjustment based on the outcome of an interim analysis, due in mid-2012.
The VALOR trial employs an innovative, adaptive trial design that allows for a one-time sample size adjustment by the DSMB at the interim analysis to maintain adequate power across a broad range of clinically meaningful and statistically significant survival outcomes.