same-sense mutation

same-sense mutation

A phenotypically silent DNA mutation caused by a point mutation that gives rise to a different codon, which is transcribed as a “synonymous” codon, and the same amino acid is incorporated into the growing polypeptide as would have been incorporated by the original, non-mutated codon; the protein remains unchanged.
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References in periodicals archive ?
In order to better characterize genetic variation of the P16 fragment within the sheep KRT85 gene, the amplified polymorphic DNA fragments were sequenced and three mutations (a silent mutation EX3_49delA, a nonsense mutation EX3_ 210G/A, and a same-sense mutation EX3_354G/A), were detected (Figure 2E).
The results revealed 20 mutation sites, IVS2+50-52insG, EX3_62delA, IVS2+85G/A, IVS2+95C/T, EX7_113G/A, EX7_117C/A, EX7 _118T/A, EX7_119T/C, EX7_120G/A, EX7_121delC, EX3_ 49delA, and EX7_111G/C, which showed silent mutations; among all mutations, EX7_93T/C, EX7_97A/C, EX7_112A/T, EX7_126G/T, and EX3_63T/A, showed missense mutations resulting in Ile [right arrow] Thr, Glu [right arrow] Asp, Gly [right arrow] Ala, Ala [right arrow] Ser, and Se [right arrow] His; nonsense mutations EX3_83A/T and EX3_210G/A; and a same-sense mutation EX3_354G/A.